Results 111 to 118 of about 118 (118)
Assessing Capability Complexity Using Enterprise Architecture Framework
Systems Engineering, EarlyView.ABSTRACT This study proposes a structured and quantitative methodology to evaluate the holistic complexity of system‐of‐systems (SoSs), employing the Zachman Architecture Framework (ZAF) as its foundational analytical tool. A five‐phase analytical procedure is developed and empirically validated, encompassing: (1) refinement of complexity measures, (2)
Javad Bakhshi, Mahmoud Efatmaneshnik
wiley +1 more source
M. E. Grant Duff, Philosophic Liberalism and the Global Liberal Cause
History, EarlyView.Abstract Historians disagree about how best to conceptualize nineteenth‐century British Liberalism in relation to its international contexts. This article argues that we can better understand the patterns involved by interrogating individuals who bridged the worlds of partisan politics and elaborated thought.
Alex Middleton
wiley +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Computing Skinning Weights via Convex Duality
Computer Graphics Forum, EarlyView.We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley +1 more source
Conservation Biology, EarlyView.Abstract The design of experiments to investigate the combined effects of multiple stressors requires exposing target organisms to multiple combinations of stressor doses. Concurrent manipulation of stressors is often infeasible with wildlife, but long‐lasting health effects allow individual health to be used as an integrator of prior stressor exposure.
Enrico Pirotta +24 more
wiley +1 more source
The FEBS Journal, EarlyView.Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan +8 more
wiley +1 more source
Effect of Moderate Heat on TCE Reductive Dechlorination Rates in Groundwater
Groundwater Monitoring &Remediation, EarlyView.Abstract Low‐temperature heating (in the mesophilic range of ~15 to 40 °C) of contaminated aquifers offers the prospect of increasing the rates for biotic and abiotic treatment of volatile organic compounds. Thermal In Situ Sustainable Remediation (TISR®) is one of the approaches available to implement low temperature heating.
David L. Freedman +3 more
wiley +1 more source
Groundwater Monitoring &Remediation, EarlyView.Abstract Characterizing the concentration and mass flux spatial distributions at sites with complex hydrogeologic conditions is critical to evaluate the fate and transport of contaminants, as well as to design effective remediation programs. PFAS (per‐ and polyfluoroalkyl substances)‐contaminated sites are even more complex due to the large number of ...
W. Andrew Jackson +8 more
wiley +1 more source