Linearizing and Forecasting: A Reservoir Computing Route to Digital Twins of the Brain
Advanced Science, EarlyView.A new approach uses simple neural networks to create digital twins of brain activity, capturing how different patterns unfold over time. The method generates and recovers key dynamics even from noisy data. When applied to fMRI, it predicts brain signals and reveals distinctive activity patterns across regions and individuals, opening possibilities for ...
Gabriele Di Antonio +3 more
wiley +1 more source
Optic axis mapping with catheter-based polarization-sensitive optical coherence tomography. [PDF]
Optica, 2018 Villiger M +5 more
europepmc +1 more source
Photon‐Sphere Modes in Curved Optical Microcavities: A Black‐Hole Analogue Laser
Advanced Science, EarlyView.An optical analogue of a Schwarzschild black hole is realized using curved microcavities that preserve light‐like geodesics. A new family of laser modes confined around the photon sphere is identified alongside conventional whispering‐gallery modes. Analytical theory, numerical simulations, and experiments reveal curvature‐induced confinement, enabling
Chenni Xu +9 more
wiley +1 more source
Е-кадеринот и неговата улога кај пациентки Ñо Ñерозен оваријален карцином во напреднат Ñтадиум [PDF]
, 2017 Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
ÐлулоÑки, Игор
core +1 more source
Modeling breast cancer progression to bone: how driver mutation order and metabolism matter. [PDF]
BMC Med Genomics, 2019 Ascolani G, Liò P.
europepmc +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. [PDF]
Acta Crystallogr D Struct Biol, 2016 Barciszewski J +6 more
europepmc +1 more source
Advanced Science, EarlyView.Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi +10 more
wiley +1 more source
An online peak extraction algorithm for ion mobility spectrometry data. [PDF]
Algorithms Mol Biol, 2015 Kopczynski D, Rahmann S.
europepmc +1 more source
Advanced Science, EarlyView.ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao +12 more
wiley +1 more source