Results 151 to 160 of about 197 (164)

The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies

Angewandte Chemie, EarlyView.
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Biswa P. Mishra, Ben Cristofori‐Armstrong, Elena Budusan, Mimi Golder, Neville J. Butcher, Junyu Liu, Theo Crawford, Yanni K.‐Y. Chin, Anneka Pereira Schmidt, Xinying Jia, Taylor B. Smallwood, Richard J. Clark, Jan P. Wurm, Lachlan D. Rash, Mehdi Mobli   +14 more
wiley   +2 more sources

Diverse Genetic Etiologies of Unilateral Polymicrogyria

Annals of Neurology, EarlyView.
Objective Polymicrogyria (PMG) is one of the most common human malformations of cortical development and is often classified by its radiographic pattern of distribution. Unilateral polymicrogyria (uPMG) is a subtype of PMG affecting a portion or all of one cerebral hemisphere.
Abbe Lai, Jennifer E. Neil, Shyam K. Akula, Dina Amrom, Eva Andermann, Ann Bergin, Roberto Caraballo, Allen Y. Chen, John Gaitanis, Ganeshwaran H. Mochida, Jill M. Gotoff, Giorgi Kuchukhidze, Daphna Marom, Christelle Moufawad ElAchkar, Miriam Regev, Lance H. Rodan, Heather Olson, Bo Zhang, Annapurna Poduri, Diane D. Shao, Christopher A. Walsh, Edward Yang   +21 more
wiley   +1 more source

Tetraaza[7]–[15]helicenes Synthesized by Two‐Step Strategy: Length‐Controlled Chiral π‐Systems Exhibiting Amplified Circularly Polarized Luminescence

Angewandte Chemie, EarlyView.
A modular two‐step strategy provides tetraaza[n]helicenes (n = 7–15) as a homologous series with tunable photophysical and chiroptical properties. Extension beyond n = 11 induces pronounced through‐space π–π interactions, narrowing the energy gap and amplifying circularly polarized luminescence.
Takashi Otani, Yuchen Wu, Kohei Ueda, Yuki Ikeda, Yuna Tada, Natsuna Kinoshita, Takanori Shibata   +6 more
wiley   +2 more sources

Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort

Annals of Neurology, EarlyView.
Objective Genomic sequencing leaves >50% of dystonia‐affected individuals without a diagnosis. Where DNA‐oriented approaches remain insufficient, integrating multiomics is essential to advance genome interpretation. Herein, we incorporated RNA sequencing (RNA‐seq) data from 167 patients with dystonia across a range of ages and presentations. Methods We
Alice Saparov, Ivana Dzinovic, Theresa Brunet, Vicente A. Yépez, Florian Hölzlwimmer, Elisabetta Indelicato, Birgit Assmann, Susann Badmann, Diana Ballhausen, Steffen Berweck, Felix Brechtmann, Melanie Brugger, Kevork Derderian, Felix Distelmaier, Philip Harrer, Denisa Harvanova, Petra Havrankova, Ann‐Kathrin Jaroszynski, Miriam Kolnikova, Robert Kopajtich, Anne Koy, Magdalena Krygier, Lukas Kunc, Katarina Kusikova, Oliver Maier, Maria Mazurkiewicz‐Bełdzińska, Christian Mertes, Ava Oberlack, Timo Roser, Alexandra Sitzberger, Ugo Sorrentino, Antonia M. Stehr, Katharina Vill, Matias Wagner, Holger Prokisch, Sylvia Boesch, Jan Necpal, Robert Jech, Juliane Winkelmann, Elisabeth Graf, Julien Gagneur, Matej Skorvanek, Michael Zech   +42 more
wiley   +1 more source

Multimaterial Triphasic Scaffold Replicates Enthesis Microenvironment to Modulate Early Cell Responses

Advanced NanoBiomed Research, EarlyView.
A bioinspired triphasic scaffold integrating 3D printed polycaprolactone and electrospun poly(lactic‐co‐glycolic acid) is developed to replicate the organization of the tendon‐to‐bone enthesis. Cyclic mechanical stimulation induces spatially defined cell morphology and lineage‐related gene expression in human mesenchymal stem cells, highlighting the ...
Ginevra Pegollo, Simone Micalizzi, Girish Pattappa, Philipp Stahlhut, Jürgen Groll, Carmelo De Maria, Denitsa Docheva, Giovanni Vozzi   +7 more
wiley   +1 more source

Rapid and Stereoselective Ring‐Opening Polymerization of rac‐Lactide Enabled by a Chiral Cyclopropenimine–Thiourea Catalyst

Angewandte Chemie, EarlyView.
Chiral cyclopropenimine–thiourea organocatalysts enabled both high reactivity and precise stereocontrol in the ring‐opening polymerization of rac‐lactide. The bifunctional system exhibited a TOF up to 1,710 h−1 with Pm = 0.90 at 25°C, and achieved Pm = 0.99 at −78°C while maintaining a TOF of 16.3 h−1.
Sumin Lee, Hooseung Lee, Hyeongwoo Nam, Seungyun Jo, Minseong Kim, Dongwook Kim, Du Yeol Ryu, Sarah Yunmi Lee, Byeong‐Su Kim   +8 more
wiley   +2 more sources

Bridged Pyrroloindole‐CAYC‐Gold Complexes: Harnessing Weak Secondary Intramolecular Au···H−C(sp3) Interactions in Gold(I) Catalysis

Angewandte Chemie, EarlyView.
We present a new class of electronically and sterically hindered N‐heterocyclic carbenes, referred to as bridged cyclic (amino)ylide carbene (bCAYC), where 9H‐pyrrolo[1,2‐a]indole acted as carbene core and diaryl sulfonium as ylide partner. Corresponding bCAYC‐Au(I) exhibits a weak secondary intramolecular Au···H−C(sp3) interaction as a secondary ...
Sourav Sekhar Bera, Anurag Kumar, Pengcheng Gao, Sanghamitra Das, Roger Lalancette, Roman Szostak, Michal Szostak   +6 more
wiley   +2 more sources

Thin and Compact Versus Thick and Porous Fouling Layers in the Emulsion Polymerization of Acrylates and Vinyl Acetates Studied In Situ With a Quartz Crystal Microbalance (QCM)

Journal of Applied Polymer Science, EarlyView.
ABSTRACT Building on a quartz crystal microbalance with dissipation monitoring (QCM‐D), fouling in emulsion polymerization was compared between acrylate dispersions stabilized with a mobile, anionic surfactant and dispersions of poly(vinyl acetate‐co‐vinyl neodecanoate), PVAc, stabilized with polyvinyl alcohol, PVOH.
K. M. Hoffmann, O. Sidorow, W. Augustin, S. Scholl, A. Langhoff, D. Johannsmann   +5 more
wiley   +1 more source

Assessing the viability of genebanked seeds from rare, wild plants native to the United States using the D.E.A.D. paradigm

Applications in Plant Sciences, EarlyView.
Abstract Premise Genebanks must maintain viable seeds for decades. Seeds that germinate are clearly alive, but some seeds, often from wild populations, do not germinate because they are dormant, empty, aged, or damaged (D.E.A.D.). This work evaluates the effects of D.E.A.D.
Christina Walters, Lisa M. Hill, Katherine D. Heineman, Hannah M. Tetreault, Shaimaa Ibrahim, Katherine Markstein, Cheryl Birker, Kris Freitag, Dustin Wolkis, Michael Kunz, Sheila Murray, Nathaniel Kingsley, Alexandra Seglias, Nicholas Matsumoto, Thomas N. Kaye, Cheryl Peterson, Matthew A. Albrecht, Noah Dell, Stacy Anderson, Steve Blackwell, David Remucal, Wendy Gibble, Anita Tiller, Emily Coffey, Jason Ligon, Laurie Blackmore, Carrie Radcliffe, Heather E. Schneider, Kristen Nelson, David Sollenberger, Jessamine Finch, Kate Wellspring, Robert Jetton, Joyce Maschinski   +33 more
wiley   +1 more source

Ultrafast Control of Coherent Acoustic Lattice Dynamics in the Transition Metal Dichalcogenide Alloy WSSe

Advanced Physics Research, EarlyView.
Coherent acoustic phonons are generated and optically controlled in bulk WSSe alloy samples using ultrafast spectroscopy. The alloy exhibits a strong coherent acoustic response, which is not an intermediate state between WS? and WSe?. Instead, a much more complex mechanism is proposed.
Sergio I. Rey, Martin J. Cross, Malte L. Welsch, Frederik Schröder, William V. Carstensen, Oleg Semyonov, Daphne M. Dekker, Nikolai Orlov, Binbin Zhou, Nicolas Stenger, Peter U. Jepsen, Edmund J. R. Kelleher   +11 more
wiley   +1 more source