Results 101 to 110 of about 8,497,150 (259)

СÑавниÑелÑнÑй анализ ÑпекÑÑов ÑоÑолÑминеÑÑенÑии ÑÑда оÑганиÑеÑÐºÐ¸Ñ Ñоединений

, 2017
Григорий Андреевич Верхоглядов
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

ÐÑоÑеÑÑионалÑÐ½Ð°Ñ Ð¸ ÑизиÑеÑÐºÐ°Ñ Ð¿Ð¾Ð´Ð³Ð¾Ñовка военноÑлÑжаÑÐ¸Ñ Ð¡Ð¨Ð

, 2017
Валерий Александрович Щеголев, Валерий Петрович Сущенко   +1 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

DETERMINAÇÃO EM D(D) E D(18O) EM ÁGUAS MINERAIS BRASILEIRAS

Revista Águas Subterrâneas, 2012
Foi realizada, pela técnica de “Cavity Ring Down Spectrometry” (CDRS) a determinação dos valores de δ(D) e δ(18O) em setenta e cinco águas minerais brasileiras engarrafadas.
JOSE MARCUS DE OLIVEIRA GODOY, MARIA LUIZ DUARTE PINTO GODOY   +1 more
doaj  

ACUTE VIRAL HEPATITIS Ð

, 1999
P Manolov, Diana Radkova
openalex   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

ÐÑÑледование возможноÑÑи ÑÑÐ¸Ð»ÐµÐ½Ð¸Ñ ÑоÑоÑока в геÑеÑоÑÑÑÑкÑÑÑÐ°Ñ II - Ñипа на оÑнове ÑзкозоннÑÑ Ð¿Ð¾Ð»ÑпÑоводников Ð3Ð5

, 2017
Андрей Юрьевич Глотов
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Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

ÐÑенка ÑÑÑекÑивноÑÑи внедÑÐµÐ½Ð¸Ñ ÐÐШ на плаÑÑоÑме SAP-HR на пÑимеÑе гÑÑÐ¿Ð¿Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¹ «ÐÐ-Рл

, 2016
Анастасия Олеговна Зубова
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