Results 131 to 140 of about 8,577,289 (274)

D-serine and D-alanine supplementation protects against chronic kidney disease. [PDF]

Sci Rep
Nakade Y, Iwata Y, Toyama T, Kobayashi T, Mita M, Yamamura Y, Oshima M, Tokumaru T, Kitajima S, Shimizu M, Sakai N, Wada T.   +11 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Positive/negative binocular fusional C-optotypes and 2D planar C-optotypes on transient accommodation and stability in adult eyes: implications for myopia prevention and control. [PDF]

Int J Ophthalmol
Fan QX, Lin J, Xu L, He W.
europepmc   +1 more source

Ðнализ влиÑÐ½Ð¸Ñ ÑезÑлÑÑаÑов деÑÑелÑноÑÑи доÑеÑÐ½Ð¸Ñ Ð¾ÑганизаÑий на показаÑели ÑинанÑовой оÑÑеÑноÑÑи Ñ Ð¾Ð»Ð´Ð¸Ð½Ð³Ð°

, 2017
Елизавета Вадимовна Попкова
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Improved hemodynamic and cardiorespiratory instability with vitamin D supplementation in an obstructive sleep apnea rat models. [PDF]

Saudi Pharm J
Alotaibi AA, Habib SS, Gad H, Al Doheyan T, Aldosary M, Aljasham AT, Alotaibi AF, Alshawakir YA, Al-Masri AA.   +8 more
europepmc   +1 more source

Modenidentifikation des variablen ð - Scuti Sternes EE-Camelopardalis mittels hochauflösender Spektroskopie

, 2014
Lukas Taudt
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Discovery of dihydrospiro[cyclopropane-1,7'-pyrrolo[3,4-<i>d</i>]pyrimidine] derivatives as novel ATR inhibitors. [PDF]

RSC Med Chem
Chen X, Qian Y, Guo Y, Li J, Xu L, Zeng X, Jiang K, Zhou Y, Li J, Liu T.   +9 more
europepmc   +1 more source

ÐÑобенноÑÑи депозиÑной полиÑики ÑовÑеменного коммеÑÑеÑкого банка (на пÑимеÑе ÐÐР«ÐТР24»)

, 2016
Александра Юрьевна Абросимова
openalex   +1 more source