Regioselective Synthesis of 1,2,3-Trisubstituted Pyrroles via Addition-Cyclization of Crotonate-Derived Sulfonium Salts with a Carboxylic Acid and an Amine. [PDF]
Chavan LN +3 more
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Prevalence of Vitamin D Deficiency in Military Dependent Infants in Hawai'i. [PDF]
Smith MF +4 more
europepmc +1 more source
The problem of pronouncing the English th sounds /θ/ and /ð/ of Vietnamese learners
Cong Khanh Ly
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Application of COI-LAMP for Detection of Dirofilaria immitis with High Sensitivity and Specificity in Epidemiological Studies. [PDF]
Genc MG, Erol U, Sahın OF, Altay K.
europepmc +1 more source
Ð.Ð.; ÐаÑÑоналÑний авÑаÑÑйний ÑнÑвеÑÑиÑÐµÑ ÐаÑÑйÑик +2 more
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A case series of hypercalcemia associated with pembrolizumab therapy: evidence for a calcitriol-mediated mechanism. [PDF]
Belcher V +5 more
europepmc +1 more source

