Patient and provider perspective with the use of a central intake system (CIS) for surgical waitlist management: a systematic review. [PDF]
Kennedy L, Asante BO, Clement F.
europepmc +1 more source
One Piece of the Puzzle: Notes on the Historic Interdental Fricatives /θ, ð, ðˁ/ in the Arabic Dialect of Gaza City [PDF]
William M. Cotter
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Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza+3 more
wiley +1 more source
Management of rickets: the new horizons for the pediatrician. [PDF]
Tonny RT+4 more
europepmc +1 more source
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh+5 more
wiley +1 more source
Relationship Between Vitamin D Supplementation and Platelet Parameters, Platelet Aggregation and Thrombosis in Healthy Adult Male Dogs: A Pilot Study. [PDF]
Daneshpour P+3 more
europepmc +1 more source
Зачем программирование грамотному человеку? (Ñ Ñ Ñ Ðµ)
Ivan Travkin
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RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha+10 more
wiley +1 more source
Exploring perceptions of vitamin D deficiency and cultural influences in people from minority ethnic groups aged 60 + in East London: a qualitative study. [PDF]
Zheng C, Teakle A, Gill R, Oyebode O.
europepmc +1 more source
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou+5 more
wiley +1 more source