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Results 91 to 100 of about 8,608,071 (248)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source

, 2017
The aim of this study was to evaluate the efficacy of using appropriate biomarkers of inflammation for diagnosis of tuberculosis in children, monitoring the disease and the effects of the applied therapy.Material and methods: In this study, 60 ...
ÐœÐ¸Ñ€Ñ‡ÐµÐ²ÑÐºÐ° (Mirchevska), Ð’Ð¸Ð¾Ð»ÐµÑ‚Ð° (Violeta)
core +1 more source

Pengaruh Media Pembelajaran Berbasis Ict Terhadap Kemandirian Dan Hasil Belajar Matematika [PDF]

, 2020
Pembelajaran menggunakan teknologi informasi dan komunikasi (ICT) sangat diperlukan di sekolah saat ini. Media pembelajaran berbasis ICT dapat menumbuhkan kemandirian belajar dan meningkatkan hasil belajar matematika siswa.
Dewi Soewardini, Herfa Maulina, Meilantifa, Meilantifa, Nadhifah, Nur +2 more
core +1 more source

Techniques and Methods for Detection and Diagnosis of Oral Premalignant and Malignant Lesions [PDF]

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source

, 2017
Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
ÐÐ»ÑƒÐ»Ð¾ÑÐºÐ¸, Ð˜Ð³Ð¾Ñ€
core +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source

astrophysics
b physics
hadron-hadron scattering experiments