Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Adiponectin and Leptin—Considerations in Adult Patients with Spinal Muscular Atrophy Type 3
DiagnosticsBackground: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder characterized by the degeneration of alpha motor neurons in the spinal cord, leading to progressive proximal muscle weakness and paralysis.
Marija Miletić +7 more
doaj +1 more source
To $${d}$$ d , or not to $${d}$$ d : recent developments and comparisons of regularization schemes
European Physical Journal C: Particles and Fields, 2017 We give an introduction to several regularization schemes that deal with ultraviolet and infrared singularities appearing in higher-order computations in quantum field theories.
C. Gnendiger +18 more
doaj +1 more source
ОÑтеогенеза и рехабилитација кај пертрохантерни фрактури Ñо dynamic hip screw- ДХС [PDF]
, 2017 Ovarian cancer is the fifth leading cause of cancer deaths and has the highest mortality rate among gynecologic cancers in women in North America and Europe.The aim of this study wasto analyze the correlation between E-cadherin expression and clinical ...
ПопоÑка (Poposka), ÐнаÑтаÑика (Anastasika) +4 more
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
ТранÑпериотонеална радикална нефректомија во третманот на карциномот на бубрег: компликации [PDF]
, 2016 Ðаnравен е преглед на наашето хируршко иÑкуÑтво Ñо интра и поÑтоnеративните компликации, документирано кај 275 пациенти Ñо карциноми на бубрег
ПетровÑки, Д +1 more
core +1 more source
Kорелација помеѓу средниот артериски притисок (МАР) и мозочната сатурација (rSO2) кај пациенти подложени на хипотензивна општа анестезија при септо- и ринопластика [PDF]
, 2019 Hypotensive anesthesia is such anesthetic technique where during general anesthesia the patient's mean arterial pressure is decreased by more than 20% of its preoperative value.
Klisevska Ilcevska, Ivana +3 more
core +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Body Dysmorphic Disorder and Aesthetic Surgery [PDF]
, 2015 ОСÐОВÐ: Дизморфофобија, или на англиÑки Body Dismorphic Disorder (BDD) е релативно чеÑто и многу тешко заболовање кое многу пати поминува недијагноÑÑ‚Ð¸Ñ†Ð¸Ñ ...
Breshkovska, Hristina +3 more
core +2 more sources