Results 171 to 180 of about 6,167,323 (251)

Taserwest neɣ tafeltira deg umezgun n Ǧamal Benɛuf : Bu Tfuset akked Aneggaru ad yerr tawwurt d imedyaten.

Ussnan
Ǧamal Benɛuf d yiwet seg tgejda n umezgun n teqbaylit, ladɣa s tsuqilin d tserwestin i yexdem i tmiga n yimura igraɣlanen yettwasnen, am tmezgunin n Johann Wolfgang von Gothé akked Tawfiq Lḥakim.
Chabha Ben Matouk
doaj  

Proteomic and genetic predictors and risk scores of cardiovascular diseases in persons living with HIV. [PDF]

Front Cardiovasc Med
Mehta T, Haine L, Baker J, Reilly C, Duprez D, Mistry SS, Steffen BT, Jain MK, Arenas-Pinto A, Polizzotto M, Staub T, Safo SE.   +11 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

The value of corporate hedging and market expectations

Full text in Russian. Executive summary in English is available at pp.37.corporate risk, hedging, market efficiency, case Tufano, portfolio approach, корпоративные риÑки, хеджирование, ÑффективноÑÑ‚ÑŒ рынкР...
Okulov, Vitaly L.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Liraglutide Modulates Zinc Release and Improves Mitochondrial Function in Insulin-Resistant Senescent Cardiomyocytes. [PDF]

Cardiovasc Toxicol
Hosseinpourshirazi F, Mendes UD, Aksoy ZB, Aydos D, Sözer M, Aljaser L, Gundogdu M, Sık S, Tuncay E, Turan B, Olgar Y.   +10 more
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

高齢者介護における組織的な職業性ストレス対策の試みとその評価 [PDF]

, 2012
横山 さつき
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury. [PDF]

EBioMedicine
Stewart I, Jacob J, Porter JC, Liu B, Tatler AL, Gomez N, Pugh MR, John AE, Allen RJ, Blaikley JF, Chaudhuri N, Denneny E, Fabbri L, George PM, Guillen-Guio B, Gooptu B, Hall IP, Ho LP, Jarrold I, Johnson S, Jones MG, Khan F, Mehta P, Mitchell J, Molyneaux PL, Pearl JE, Piper Hanley K, Platé M, Quinn V, Rivera-Ortega P, Saunders LC, Smith DJF, Spears M, Spencer LG, Stanel SC, Thompson AAR, Walsh S, Wild JM, Wootton DG, Docherty AB, Gleeson F, Greenhalf W, Harrison EM, Lone N, Quint J, Maslova A, Pohl M, Stephens A, Young S, Singapuri A, Shikotra A, Sereno M, Saunders RM, Richardson M, Raman B, Poinasamy K, McAuley HJC, Marks M, Leavy OC, Houchen-Wolloff L, Horsley A, Harris VC, Greening N, Evans RA, Elneima O, Chalmers JD, Brightling CE, Chambers RC, Wain LV, Jenkins RG, PHOSP-COVID Collaborative Group and the UKILD Consortium.   +70 more
europepmc   +1 more source