FoxO1 signaling in B cell malignancies and its therapeutic targeting
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac+3 more
wiley +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
ДејÑтво на интерферон врз фагоцитоза на леукоцитите во in vitro уÑлови [PDF]
In atempt to get elementary insight of interpheron action on leukocyte fagocytable capacity, in vitro were tested fagocytes from the patients with various diseases.
УгринÑки (Ugrinski), Предраг (Predrag)+1 more
core +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
T Through the article, we will provide an entirely novel type of quasi operators base on the concept of D razin inverse in Operator theory which is named (n,D) -quasi operators on the Hilbert spaces, also we explain the sum, product, and other features ...
salim dawood mohsen
doaj +1 more source
Riscos associados à água destinada ao consumo humano e as vulnerabilidades das populações urbanas
O s e r h u m a n o s e e n c o n t r a e x p o s t o a d i v e r s o s t i p o s d e r i s c os c o m r e c o n h e c i d o s e f e i t o s à s a ú d e .
Luis Henrique Batista Gois
doaj +1 more source
Радиоимунолошко одредување на нормални предпладневни вредноÑти на ÐЦТХ и кортизол во плазмата кај женÑки и машки иÑпитаници [PDF]
Basal levels of ACT and cortisol in the plasma show diurnal, menstrual and gravidities variations. Several authors have presented mean value with large deviations making difficulties in the clinical interpretation of the results.In order to get more real
Ðикодијевиќ (Nikodijevikj), Олга (Olga)+1 more
core +1 more source
Structure of Patients Treated in Intensive Coronary Care Unit on Department for Internal Medicine – PHO General Hospital Kumanovo – in the Period from 2009-2013 Year [PDF]
ОСÐОВÐ: Главната функција на коронарната единица е доÑтапноÑÑ‚ на телеметрија или континуирано Ñледење на Ñрцевиот ритам и крвниот притиÑок пр
Anchevski, Tomica
core +2 more sources