Results 91 to 100 of about 109 (108)

From Cold to Hot: Nanozyme‐Based Strategies for Reprogramming the Tumour Immunoenvironment

Cell Proliferation, EarlyView.
Nanozymes, with multi‐enzyme catalytic activities, reprogram the immunosuppressive tumour microenvironment by inducing immunogenic cell death, relieving hypoxia, and depleting antioxidants, effectively converting immunologically “cold” tumours into “hot” ones to boost cancer immunotherapy efficacy.
Yue Wang, Miao Xu, Yongshun Wang, Xuan Lin, Qiang Zhang, Xiaoning Lin, Xin Wu, Cheng Zhang, Wenhua Huang, Jianlin Shen   +9 more
wiley   +1 more source

Clinical characteristics and follow‐up of 77 patients with pathogenic fumarate hydratase variants

BJU International, EarlyView.
Matthijs Duijn, Aline M. Tijans, R. Jeroen A. van Moorselaar, Marjoleine F. Broekema, Marleen E. de Lange, Emiel D. Post Uiterweer, Marilyne M. Lange, Naomi Donner, Markus V. Starink, Antoinette Hollestelle, Liselotte P. van Hest, Femke Struik, Patricia J. Zondervan   +12 more
wiley   +1 more source

Exoskeleton‐assisted physiotherapy in school and outpatient contexts for minimally ambulant children with cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To assess the clinical feasibility of lower‐limb pediatric exoskeleton‐assisted (Trexo Plus) physiotherapy for minimally ambulatory children at an outpatient center and a primary school. Secondary aims were to assess associated functional and goal‐based outcomes before and after Trexo‐based physiotherapy.
Stefanie S. Bradley, Tom Chau, Anne Kawamura, F. Virginia Wright   +3 more
wiley   +1 more source

Outcomes of children and young people with cerebral palsy receiving long‐term respiratory support: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Outcomes of children with cerebral palsy receiving long‐term respiratory support. Abstract Aim To systematically review the current knowledge gap in, and impact of, long‐term respiratory support in children and young people (CYP) with cerebral palsy (CP). Method We searched six databases from inception until 30th January 2025.
Rajkumar Dhandayuthapani, Alasdair Campbell, Catherine M McDougall, Florian Gahleitner, Steve Cunningham, Don S Urquhart   +5 more
wiley   +1 more source

Honouring the Past, Embracing the Future

The Ecumenical Review, EarlyView.
Abstract The United Church of Canada, founded in 1925, represents an ambitious experiment in church union that blends Methodist, Presbyterian, and Congregationalist traditions. Over the past century, the church has played a pivotal role in shaping Canadian society by advocating for social justice, Indigenous reconciliation, interreligious dialogue ...
Hyuk Cho
wiley   +1 more source

Considerations for the Design of Sinusoidal Slug Testing Methods

Groundwater, EarlyView.
Periodic hydraulic tests estimate aquifer properties using controlled groundwater‐level oscillations. Evaluating two sinusoidal slug‐test designs shows large motion errors when transfer‐link and flywheel ratios are high or variable. Rotating‐drive mechanisms are therefore suboptimal; stepper‐motor winches generate more accurate sinusoidal motion ...
Chris Turnadge, Lawrence Burk, Eddie W. Banks   +2 more
wiley   +1 more source

FVIIIa Mimetics: New Approaches and Next‐Generation Initiatives

Haemophilia, EarlyView.
ABSTRACT Emicizumab has revolutionized hemophilia A care, yet limitations regarding the “ceiling” of hemostatic efficacy (equivalent to mild hemophilia) and global access persist. This review critically examines two distinct paradigms shaping the future of care: Innovation and Access. Regarding innovation, we synthesize the latest clinical data on next‐
Tadashi Matsushita, Keiji Nogami, Chandrakala Shanmukhaiah   +2 more
wiley   +1 more source

Clinical and Psychosocial Predisposing Factors Associated With Anaesthesia Failure During Non‐Surgical Root Canal Treatment: A National Dental Practice‐Based Research Network Study

International Endodontic Journal, EarlyView.
ABSTRACT Aim This study aimed to identify dentist, patient, and pre‐treatment clinical characteristics associated with local anaesthesia failure during non‐surgical endodontic treatment. Methodology Data were collected from the National Dental Practice‐Based Research Network study entitled “Predicting Outcomes of Root Canal Treatment (PREDICT)”, which ...
Linda J. Liu, Ronald Ordinola‐Zapata, W. Craig Noblett, Ellen Funkhouser, Alan S. Law, Donald R. Nixdorf, Ernest W. N. Lam, Rahma Mungia, Gregg H. Gilbert, The National Dental Practice‐Based Research Network Collaborative Group   +9 more
wiley   +1 more source

Cytogenetic Diversity of Variant Philadelphia Translocations in Chronic Myeloid Leukemia

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Chronic myeloid leukemia (CML) is a disease characterized by Philadelphia (Ph) translocations. These translocations can be classical or variant. The structural features and diagnostic implications of variant Philadelphia translocations remain incompletely defined, and they display considerable cytogenetic heterogeneity. Methods In
Ayse Gul Bayrak Tokac, Aynur Aday, Simge Erdem, Gulcin Bagatir, Burak Don, Ozden Ozcan, Akif Selim Yavuz, Sevgi Kalayoglu Besisik, Meliha Nalcaci, Kivanc Cefle, Sukru Ozturk   +10 more
wiley   +1 more source

Which Aspects of Abortion Care Do Healthcare Practitioners in Britain Think Nurses/Midwives Should Provide? Findings From the SACHA Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To explore the views of healthcare practitioners in Britain regarding the role of midwives and nurses in the delivery of medical and surgical abortion. Design An observational study of the Shaping Abortion for Change study healthcare practitioner survey (2021–2022).
Alice Fulton, Ona McCarthy, Jill Shawe, Rebecca Meiksin, Maria Lewandowska, Melissa Palmer, Rachel Scott, Kaye Wellings, Patricia Lohr, Geoffrey Wong, Sally Sheldon, Rebecca French and The SACHA Study Team, Annette Aronsson, Paula Baraitser, Sharon Cameron, Louise Keogh, Clare Murphy, Wendy V. Norman, Jennifer Reiter, Natasha Salaria   +19 more
wiley   +1 more source