Results 11 to 20 of about 109 (108)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Spatial Patterning of Modular Gelatin‐Peroxide Microspheres in Melt‐Electrowritten Scaffolds Provides Controlled Oxygen Generation and Mitigates Hypoxia and Cytotoxicity

Advanced Healthcare Materials, EarlyView.
A bioassembly approach is described using photo‐crosslinked gelatin‐based microgels containing calcium peroxide (CaO2) to generate oxygen (O2) and enhance cell survival in hypoxic conditions (1% O2). Bioassembly enables spatial patterning of individual CaO2‐laden and mesenchymal stem cell (MSC)‐laden microgels and allows for decoupling and mitigating ...
Axel E. Norberg, F. Max Yavitt, Ezgi Bakirci, Khoon Lim, Tim B. F. Woodfield, Gabriella C. J. Lindberg   +5 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Boron deficiency responses in maize (Zea mays L.) roots

Journal of Plant Nutrition and Soil Science, EarlyView., 2023
Abstract Background Boron (B) is an essential micronutrient for plants. Dicot plants respond to insufficient B supply by altering root architecture and root hair growth. How root systems of rather low‐B demanding monocot species such as maize (Zea mays L.) respond to B deficiency in terra has not been experimentally resolved, yet.
Manuela Désirée Bienert, Astrid Junker, Michael Melzer, Thomas Altmann, Nicolaus von Wirén, Gerd Patrick Bienert   +5 more
wiley   +1 more source

Beyond Earth: Resilience of Quasi‐2D Perovskite Solar Cells in Space

Advanced Materials, EarlyView.
In the article (DOI: 10.1002/adma.202520433), Christoph Putz and co‐workers demonstrate rigid quasi‐2D perovskite solar cells operating in low Earth orbit, delivering stable power for more than 100 days under real‐space conditions. In‐orbit performance is correlated with extensive ground‐based thermal and proton‐irradiation studies on rigid and ...
Christoph Putz, Lukas E. Lehner, Stepan Demchyshyn, Bekele Hailegnaw, Phillip Jahelka, Magdalena Breitwieser, Sercan Özen, Andrea Denker, Jürgen Bundesmann, Alina Hanna Dittwald, Dilara Karabulut, Philipp Tockhorn, Steve Albrecht, Felix Lang, Markus C. Scharber, Michael D. Kelzenberg, Harry A. Atwater, Martin Kaltenbrunner   +17 more
wiley   +1 more source

Fabric‐Based Wearable Robotic Exoskeleton Gloves: Advancements and Challenges

Advanced Materials Technologies, EarlyView.
This review highlights interdisciplinary technological advances in fabric‐based robotic gloves, focusing on progress in design, fabrication, actuation, sensing, control, and power and energy requirements. It also addresses performance testing and validation, including biomechanical, strength, functional, user experience, and durability assessments, to ...
Ayse Feyza Yilmaz, Gökhan Ince, Ozgur Atalay   +2 more
wiley   +1 more source

A Soft Robotic Device for Targeted Massage Therapy of Residual Limbs

Advanced Robotics Research, EarlyView.
Residual limb edema after amputation can hinder recovery and delay prosthetic fitting. This study presents a soft‐robotic wearable device that delivers sequential compression through pneumatic McKibben actuators. By replicating the principles of manual lymphatic drainage, the device generates controlled mechanotherapeutic pressure patterns, providing a
Maria Grazia Polizzotto, Alessio Capecchi, Maartje Van der Lingen, Emanuele Gruppioni, Arianna Menciassi, Linda Paternò   +5 more
wiley   +1 more source

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, EarlyView.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Deformation Driven Suction Cups: A Mechanics‐Based Approach to Wearable Electronics

Advanced Science, EarlyView.
Deformation‐driven suction cups enable robust, reversible adhesion of wearable electronics to human skin spanning wide mechanical compliance, without adhesives or tight straps. By integrating mechanics modeling, experiments, and contact mechanics theory, this work reveals how cup geometry, substrate compliance, and interfacial adhesion govern suction ...
Seola Lee, Andrew Akerson, Roham Pardakhtim, Ehsan Hajiesmaili, Kevin Rhodes, Zidong Li, Andrew Stanley, Amirhossein Amini, Daniele Piazza, Chiara Daraio, Tianshu Liu   +10 more
wiley   +1 more source