Results 81 to 90 of about 156 (151)

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

open access: yesAdvanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu   +18 more
wiley   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

open access: yesAdvanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal   +15 more
wiley   +1 more source

Geometrically Confined Strain Engineering of MoS2 via Quasi‐Van Der Waals Recrystallization of Gold Nanopillars

open access: yesAdvanced Science, EarlyView.
Geometrically confined quasi‐van der Waals (qvdW) recrystallization of patterned gold induces localized tensile strain in monolayer MoS2, enhancing its optoelectronic performance. The strain, induced during annealing after hBN encapsulation, leads to a 65‐fold increase in photoluminescence and a two‐order magnitude boost in mobility, offering a ...
Kyungmin Yang   +7 more
wiley   +1 more source

Medium‐Entropy Engineering Enhances Na⁺/Electron Transport in Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs Cathode for Sodium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
This study proposes a medium‐entropy strategy to enhance sodium vanadium fluorophosphate cathodes. The designed Na3Fe0.1Mn0.2Co0.2Ni0.3V1.2(PO4)2F3@CNTs composite enhances structural stability and charge transport. Entropy‐induced distortion and carbon nanotubes (CNTs) synergistically improve Na⁺/electron kinetics. In situ XRD reveals a reversible dual‐
Ju Yang   +7 more
wiley   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie   +18 more
wiley   +1 more source

Electroplating Carbon Nano‐Onion on Copper for Dendrite‐Free and Anode‐Free Zinc‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
Zinc‐ion batteries are emerging as safe and cost‐effective alternatives to lithium‐ion batteries, but suffer from dendrite formation and unstable anodes. An electroplating approach for preparing a carbon nano‐onion (CNO)‐embedded‐Cu layer on Cu foil is presented, which enables highly reversible zinc plating/stripping (99.89% efficiency over 1400 cycles)
Yufan Zhang   +10 more
wiley   +1 more source

Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota

open access: yesAdvanced Science, EarlyView.
Non‐invasive photobiomodulation therapy (PBMT) enhances muscle endurance by rewiring the gut‐muscle axis. PBMT preserves gut epithelial integrity and enriches beneficial anaerobes, driving metabolites such as butyrate, spermidine, and L‐carnitine that supercharge mitochondrial energy in skeletal muscles.
Prabhat Upadhyay   +3 more
wiley   +1 more source

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