Results 101 to 110 of about 116 (115)

Conformational Trajectory of the Molecular Chameleon Grazoprevir from Formulation to Target‐Bound

Chemistry – A European Journal, EarlyView.
ABSTRACT Macrocycles represent a promising class of beyond‐rule‐of‐5 (bRo5) therapeutics, capable of targeting proteins traditionally considered undruggable by conventional small molecules. Macrocycles exhibit intrinsic flexibility and often display a “chameleon‐like” ability to adapt to their environment, thereby enhancing their oral bioavailability ...
Lianne H. E. Wieske, Guanhong Bu, Máté Erdélyi, Jan Kihlberg, Tamir Gonen, Emma Rova Danelius   +5 more
wiley   +1 more source

Rank‐based estimation of propensity score weights via subclassification

Canadian Journal of Statistics, EarlyView.
Abstract Propensity score (PS) weighting estimators are widely used for causal effect estimation and enjoy desirable theoretical properties, such as consistency and potential efficiency under correct model specification. However, their performance can degrade in practice due to sensitivity to PS model misspecification.
Linbo Wang, Yuexia Zhang, Thomas S. Richardson, Xiaohua Zhou   +3 more
wiley   +1 more source

Applying Machine Learning Methods to Laser Acceleration of Protons: Synthetic Data for Exploring the High Repetition Rate Regime

Contributions to Plasma Physics, EarlyView.
ABSTRACT Advances in ultra‐intense laser technology have increased repetition rates and average power for chirped‐pulse laser systems, which offer a promising solution for many applications including energetic proton sources. An important challenge is the need to optimize and control the proton source by varying some of the many degrees of freedom ...
John J. Felice, Ronak Desai, Nathaniel Tamminga, Joseph R. Smith, Alona Kryshchenko, Chris Orban, Michael L. Dexter, Anil K. Patnaik   +7 more
wiley   +1 more source

Hygroscopic Organic Complex Mutated Helmholtz Plane of Zn Anode for Outstanding Zinc Ion Battery

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Simple and commercial approach was established to in‐situ construct a hygroscopic Zn complex protective layer. This protective layer can absorb water molecules and trap it away from Zn anode. The hygroscopic layer can dehydrate the electrolyte and enhance the de‐solvation process and partial form nitrogen rich SEI which lead to reduce the mechanical ...
Abdelnaby M. Elshahawy, Yong Gao, Wenbo Zhao, Junwei Li, Haifeng Zhang, Ximeng Liu   +5 more
wiley   +1 more source

Redox‐Mediating Mo2C Nanoparticles Confined Within Nitrogen‐ and Phosphorus‐Codoped Amorphous Carbon Matrix for Lithium–Sulfur Batteries

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A multifunctional interlayer composed of Mo2C nanoparticles embedded in a nitrogen‐ and phosphorus‐doped amorphous carbon matrix on graphene is developed via electrostatic self‐assembly and thermal transformation. The resulting architecture suppresses the shuttle effect, improves electrical conductivity, and facilitates redox conversion kinetics ...
Won Il Kim, Min Ju Kim, Hyunyoung Park, Minjun Hwang, Jin Suk Byun, Jaeheon Lee, Jongsoon Kim, Ho Seok Park   +7 more
wiley   +1 more source

Reviews of High‐Longevity Aqueous Zinc Metal Batteries Achieved by Programmable Interface Architectures

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review focuses on the mechanisms of Zn2+ electrodeposition and interfacial failure together with systematical artificial interphase layer design strategies from carbon materials, zincophilic alloys, to inorganic/organic compound layers, regulating ion flux and desolvation and providing guidance for programmable interface construction in aqueous ...
Bixian Chen, Xiaomin Cheng, Haifeng Yang, Teng Li, Jing Dong, Yidong Miao, Yongzheng Zhang, Qingbo Xiao, Qinghua Guan, Jing Zhang, Yunjian Liu, Hongzhen Lin, Jian Wang   +12 more
wiley   +1 more source

Multifunctional Phosphorus Doping: Integrating Enhanced Ionic/Electronic Transport and Interface Optimization for Silicon Oxycarbide Anodes

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Phosphorus doping introduced additional electrons into silicon oxycarbide (SiOC) materials, facilitating fast ion/electron transport. It also induced the formation of more stable and Li‐ion conductive interfaces, contributing to the improvement of electrochemical performance.
Yingying Shen, Yun Zheng, Jiangmin Jiang, Yike Huang, Yinan Liu, Rong Chen, Pingshan Jia, Lifen Long, Congcong Zhang, Huaiyu Shao   +9 more
wiley   +1 more source

Bidirectional sleep‐seizure interactions and orexin in a mouse model of tuberous sclerosis complex‐related epilepsy

Epilepsia, EarlyView.
Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing, Lirong Han, Dongjun Guo, Thomas J. Foutz, Michael Wong   +4 more
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Fast ripple‐delta coupling as an early biomarker for post‐traumatic epileptogenesis in repetitive brain injury

Epilepsia Open, EarlyView.
Abstract Objective Traumatic brain injury (TBI) can induce posttraumatic epilepsy (PTE), but early biomarkers for epileptogenesis are lacking. We aimed to investigate electrographic biomarkers before and during posttraumatic seizure development. Methods We used a repetitive diffuse TBI model in mice with continuous video‐EEG monitoring up to 4½ months ...
Oleksii Shandra, Dzenis Mahmutovic, Biswajit Maharathi, Md Adil Arman, Michael J. Benko, Owen Leitzel, Pritom Kumar Saha, Stefanie Robel   +7 more
wiley   +1 more source