Results 111 to 116 of about 116 (116)
Assessing Capability Complexity Using Enterprise Architecture Framework
Systems Engineering, EarlyView.ABSTRACT This study proposes a structured and quantitative methodology to evaluate the holistic complexity of system‐of‐systems (SoSs), employing the Zachman Architecture Framework (ZAF) as its foundational analytical tool. A five‐phase analytical procedure is developed and empirically validated, encompassing: (1) refinement of complexity measures, (2)
Javad Bakhshi, Mahmoud Efatmaneshnik
wiley +1 more source
Journal of Applied Crystallography, EarlyView.A user‐friendly fixed‐target platform for serial synchrotron crystallography is described, which allows low‐background X‐ray diffraction data collection, in situ crystallization and transportation of protein microcrystals at room temperature.Fixed‐target platforms provide convenient support for microcrystals during serial X‐ray crystallography studies ...
Swagatha Ghosh +13 more
wiley +1 more source
M. E. Grant Duff, Philosophic Liberalism and the Global Liberal Cause
History, EarlyView.Abstract Historians disagree about how best to conceptualize nineteenth‐century British Liberalism in relation to its international contexts. This article argues that we can better understand the patterns involved by interrogating individuals who bridged the worlds of partisan politics and elaborated thought.
Alex Middleton
wiley +1 more source
Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Anastrozole, an aromatase inhibitor, is used to treat postmenopausal women with hormone receptor‐positive breast cancer, but also induces musculoskeletal pain and can lead to therapeutic regimen suspension. Aromatase inhibitors promote the release of pro‐inflammatory substances from sensitised nerve fibres, which might ...
Maria Fernanda Pessano Fialho +5 more
wiley +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Computing Skinning Weights via Convex Duality
Computer Graphics Forum, EarlyView.We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley +1 more source