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Results 151 to 160 of about 4,895 (165)

Heterogenous Neuropathology in a Pedigree with RAB39B‐Related Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background In 2015, we reported a family with Parkinson's disease resulting from the RAB39B p.G192R (c.574G>A) variant. Since then, two affected brothers from the family have undergone autopsy. Objectives To characterize neuropathological findings, assess intracellular distribution of RAB39B protein, and examine the effect of p.G192R on α ...
Caitlin Latimer +15 more
wiley +1 more source

Multiecho Fat‐Water Spiral MR Elastography With Distributed Encoding for Simultaneously Imaging Brain and Skull Displacement

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To introduce a novel multiecho, multishot spiral MR elastography (MRE) sequence to image brain and skull displacement simultaneously using a joint fat‐water image reconstruction and distributed motion encoding. Methods Multiple echo times were implemented into a high‐resolution multishot spiral MRE sequence to capture water‐based brain
Alexa M. Diano +8 more
wiley +1 more source

Optimizing Research Operations and Resource Utilization in ALS Care: Insights From the Tofersen Antisense Oligonucleotide Expanded Access Protocol

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Tofersen is a gene‐targeted therapy for individuals with superoxide dismutase 1 (SOD1) (+) amyotrophic lateral sclerosis (ALS). Prior to U.S. Food and Drug Administration (FDA) approval, tofersen was made available through expanded access protocol.
Alison Wheeler +30 more
wiley +1 more source

At‐Home Versus in‐Clinic Vital Capacity Measurement: Insights From the HEALEY ALS Platform Trial

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Respiratory weakness, typically monitored as vital capacity (VC), is a central feature of amyotrophic lateral sclerosis (ALS). VC is increasingly measured remotely in participants' homes, although in‐clinic assessment remains the standard.
Eric A. Macklin +269 more
wiley +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

Naval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley +1 more source

Approximate Reachability for Feedback Linearizable Systems

Optimal Control Applications and Methods, EarlyView.
The backwards reachable set for a dynamical system is the set of states for which there exists a constraint admissible trajectory that reaches a given terminal set. Conventional grid‐based approaches for computing these sets are intractable for many applications.
Vincent Liu, Chris Manzie, Peter M. Dower +2 more
wiley +1 more source

Optical mapping reveals a higher level of large‐scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease

The Journal of Pathology, EarlyView.
Abstract Myotonic dystrophy type 1 (DM1) is a clinically challenging multisystem neuromuscular hereditary disorder, with generational increase in severity and earlier age at onset. It is caused by an unstable cytosine‐thymine‐guanine repeat expansion at the DMPK locus, accompanied by associated genetic and epigenetic modifications.
Md Mehedi Hasan +9 more
wiley +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner +2 more
wiley +1 more source

A green solvent processable, self‐doped N‐annulated perylene butyl tetraester applied as a solar cell cathode interlayer

Polymer International, EarlyView.
A new organic molecular cathode interlayer is presented built upon the perylene butyl tetraester scaffold. The new molecule incorporates N‐annulation and a functional amine group to control optical, electrochemical and physical properties and delivers excellent solar cell performance. Abstract We report a new amino‐bay‐substituted, N‐annulated perylene
Kathryn M Wolfe +7 more
wiley +1 more source

Identifying Suitable Front Contacts for High‐Efficiency Cd(Se,Te) Solar Cells on Space‐Qualified Cover Glass

Progress in Photovoltaics: Research and Applications, EarlyView.
Front contact selection governs interfacial stability in CdTe‐based (Cd(Se,Te)) solar cells on ultra‐thin space‐qualified cover glass. Optimized TCO/emitter combinations suppress interdiffusion and deliver up to 16.2% AM0 efficiency with high specific power, demonstrating strong potential for lightweight space photovoltaics.
Aesha P. Patel +17 more
wiley +1 more source

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