Results 101 to 110 of about 114 (114)

What defines response to vagus nerve stimulation in children with drug‐resistant epilepsy? A prospective cohort study from the CONNECTiVOS collaboration

open access: yesEpilepsia, EarlyView.
Abstract Objectives Responsiveness to vagus nerve stimulation (VNS) in children with drug‐resistant epilepsy (DRE) is often defined based on reduction in seizure frequency, typically at the 50% threshold, with limited consideration to the effects of therapy on seizure severity and health‐related quality of life (HRQoL). In the current report, we sought
Farbod Niazi   +38 more
wiley   +1 more source

Honouring the Past, Embracing the Future

open access: yesThe Ecumenical Review, EarlyView.
Abstract The United Church of Canada, founded in 1925, represents an ambitious experiment in church union that blends Methodist, Presbyterian, and Congregationalist traditions. Over the past century, the church has played a pivotal role in shaping Canadian society by advocating for social justice, Indigenous reconciliation, interreligious dialogue ...
Hyuk Cho
wiley   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

open access: yesThe FEBS Journal, EarlyView.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés   +19 more
wiley   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

open access: yesThe FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona   +11 more
wiley   +1 more source

Differences in clinical approaches of endodontists and general dentists when performing non‐surgical root canal treatment: A prospective cohort study from the National Dental Practice‐Based Research Network PREDICT Project

open access: yesInternational Endodontic Journal, EarlyView.
Abstract Aim Information regarding differences between general dentists (GDs) and endodontists in their daily practices is limited. The aim of this prospective cohort clinical study was to compare the details of clinical approaches of GDs and endodontists when performing non‐surgical root canal treatments (NSRCT).
Ali Nosrat   +7 more
wiley   +1 more source

ObMetrics: A Shiny app to assist in metabolic syndrome assessment in paediatric obesity

open access: yesPediatric Obesity, Volume 20, Issue 8, August 2025.
Summary Objective To introduce ObMetrics, a free and user‐friendly Shiny app that simplifies the calculation, data analysis, and interpretation of Metabolic Syndrome (MetS) outcomes according to multiple definitions in epidemiological studies of paediatric populations. We illustrate its usefulness using ethnically different populations in a comparative
Álvaro Torres‐Martos   +22 more
wiley   +1 more source

Assessment of the Psychometric Properties of the Mask Usability Scale: A Measure of the Perceived Usability of N95 Respirators Among Healthcare Students and Staff

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To test the reliability and construct validity of the Mask Usability Scale in healthcare students and staff. Design A methodological study involving repeated measures. Methods The study included two batches of participants: (1) 283 university nursing students and (2) 1753 participants composed of students (61%) and clinical staff (39 ...
Lorna Kwai Ping Suen   +9 more
wiley   +1 more source

Registered Nurse‐Led Assessments in Australian Residential Aged Care Homes: A Scoping Review

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To understand the current evidence base regarding holistic nursing assessments performed by registered nurses in residential aged care homes in Australia, and identify the gaps in knowledge and potential areas for future research. Design A scoping review informed by JBI guidelines and the PRISMA extension for Scoping Reviews.
Laura Bocks   +13 more
wiley   +1 more source

The Diffusion of Deal Innovations in Complex Contractual Networks

open access: yesJournal of Empirical Legal Studies, EarlyView.
ABSTRACT We introduce a new method for studying contractual evolution in complex markets. We situate the diffusion of a deal innovation within an advisory network and then provide methods for inferring a law firm's preference for adopting the innovation and for calculating each firm's proximity to prior adopters.
Kristina Bishop   +2 more
wiley   +1 more source

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