Results 31 to 40 of about 114 (114)
Biotechnology and Bioengineering, Volume 122, Issue 8, Page 2273-2280, August 2025.ABSTRACT The rise in chronic lung diseases globally and the corresponding lag in drug discovery in this field highlights the need for In Vitro models closely mimicking In Vivo lung tissue. Efforts to date have largely focused on In Vitro coculture models, often neglecting the pulmonary vasculature's role in lung physiology and lacking perfusability. To
Sakshi Phogat +3 more
wiley +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT This study investigates the potential of Fernandoa adenophylla, a South American plant, as a reservoir of compounds with thymidine phosphorylase (TP) inhibitory activity. Through a comprehensive approach combining in vitro assays and molecular docking analysis, we isolated and characterized bioactive compounds from F.
Abdur Rauf +11 more
wiley +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.High‐impact thermoplastic starch blends through the co‐plasticization methodology. Abstract This study analyzed the effect of employing plasticized or co‐plasticized post‐industrial starch in developing PBAT‐based thermoplastic starch (TPS) blends. In this work, the post‐industrial wheat starch was co‐plasticized with glycerol‐urea, glycerol‐citric ...
Aarsha Surendren +5 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations (n = 12), the relative bioavailability of the PfOS versus tablet formulation,
Yang Zhang +6 more
wiley +1 more source
The Depositional Record, EarlyView.Five large Alpine cave systems on the Dachstein (Austria) were investigated and 35 sediment profiles or outcrops between 860 m a.s.l. and 1945 m a.s.l. were analysed. An altitude‐dependent overall stratigraphy is established and depositional conditions and palaeo‐environments are reconstructed.
Franziska Holzer +2 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem +13 more
wiley +1 more source
ESC Heart Failure, EarlyView.Among 668 with cardiogenic shock included in the multicentre prospective Altshock‐2 registry, 299 patients (44.8%) received pre‐admission beta‐blocker therapy. Previous beta‐blocker therapy influenced the early hemodynamic response to vasoactive drugs, but it was not associated with in‐hospital mortality.
Matteo Pagnesi +21 more
wiley +1 more source
Cardioprotective effects of semaglutide on isolated human ventricular myocardium
European Journal of Heart Failure, EarlyView.Semaglutide reduces late sodium current (INa) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end‐stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients. Improved Ca storage may underly the enhanced contractility of human cardiomyocytes upon semaglutide.
Thomas Krammer +16 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.Lung ultrasound (LUS) and mortality in cardiogenic shock (CS) patients. Abstract Aims Lung ultrasound (LUS) is a widely used technique to assess de‐aeration in critically ill patients with respiratory failure. There is paucity of data on LUS in cardiogenic shock (CS).
Guido Tavazzi +19 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.Kidney injury in heart failure‐related cardiogenic shock. AKI, acute kidney injury; CI, confidence interval; eCPR, extracorporeal cardiopulmonary resuscitation; eGFR, estimated glomerular filtration rate; HR, hazard ratio; OR, odds ratio; VA‐ECMO, veno‐arterial extracorporeal membrane oxygenation.
Jonas Sundermeyer +41 more
wiley +1 more source