Results 101 to 110 of about 113 (113)

The far side of capitalism: Institutions and trade financing in Manila during the long eighteenth century

open access: yesThe Economic History Review, EarlyView.
Abstract Sustained long‐distance trade in the early modern era necessitated institutional mechanisms capable of solving three interrelated challenges: the need to mobilize an unprecedented volume of capital and to lock it in for long periods of time, ways of mitigating the principal–agent problem across continents, and methods to internalize and ...
Juan José Rivas Moreno
wiley   +1 more source

A century of art dealing in New York. The rise of American art

open access: yesThe Economic History Review, EarlyView.
Abstract We study art trade in New York between 1870 and 1970, analysing returns on investment by the renowned Knoedler gallery to shed light on the evolution of the American art market. A generalist art gallery should allocate investments to equalize expected returns, with differences in effective returns depending on purchase prices, number of traded
Federico Etro, Elena Stepanova
wiley   +1 more source

Deep brain stimulation of the centromedian nucleus for drug‐resistant epilepsy in children: Quality‐of‐life and functional outcomes from the CHILD‐DBS registry

open access: yesEpilepsia, EarlyView.
Abstract Objective Deep brain stimulation of the centromedian nucleus of the thalamus (CM‐DBS) is an investigational, off‐label treatment for drug‐resistant epilepsy (DRE) in children. Although emerging evidence supports its safety and efficacy for select indications, the effect of CM‐DBS on quality of life and functional outcomes such as school ...
Karim Mithani   +21 more
wiley   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

open access: yesThe FEBS Journal, EarlyView.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés   +19 more
wiley   +1 more source

The CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis

open access: yesThe FEBS Journal, EarlyView.
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Cristian Andres Carmona‐Carmona   +11 more
wiley   +1 more source

Beyond Surface Level: Evaluating Spatial Incongruencies in High‐Resolution Bottom Temperature Trends for the Gulf of Mexico, 1996–2012

open access: yesFisheries Oceanography, EarlyView.
ABSTRACT Semi‐enclosed seas present complex and nonlinear challenges to understanding climate impacts on fisheries because continental margins restrict poleward movement by taxa seeking to maintain preferred temperatures. The Gulf of Mexico (GoM), a semi‐enclosed, marginal sea surrounded by the North American continent, supports many economically and ...
Jill C. Thorr   +4 more
wiley   +1 more source

ObMetrics: A Shiny app to assist in metabolic syndrome assessment in paediatric obesity

open access: yesPediatric Obesity, EarlyView.
Summary Objective To introduce ObMetrics, a free and user‐friendly Shiny app that simplifies the calculation, data analysis, and interpretation of Metabolic Syndrome (MetS) outcomes according to multiple definitions in epidemiological studies of paediatric populations. We illustrate its usefulness using ethnically different populations in a comparative
Álvaro Torres‐Martos   +22 more
wiley   +1 more source

Assessment of the Psychometric Properties of the Mask Usability Scale: A Measure of the Perceived Usability of N95 Respirators Among Healthcare Students and Staff

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To test the reliability and construct validity of the Mask Usability Scale in healthcare students and staff. Design A methodological study involving repeated measures. Methods The study included two batches of participants: (1) 283 university nursing students and (2) 1753 participants composed of students (61%) and clinical staff (39 ...
Lorna Kwai Ping Suen   +9 more
wiley   +1 more source

Registered Nurse‐Led Assessments in Australian Residential Aged Care Homes: A Scoping Review

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To understand the current evidence base regarding holistic nursing assessments performed by registered nurses in residential aged care homes in Australia, and identify the gaps in knowledge and potential areas for future research. Design A scoping review informed by JBI guidelines and the PRISMA extension for Scoping Reviews.
Laura Bocks   +13 more
wiley   +1 more source

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