Results 11 to 20 of about 114 (114)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Boron deficiency responses in maize (Zea mays L.) roots

Journal of Plant Nutrition and Soil Science, EarlyView., 2023
Abstract Background Boron (B) is an essential micronutrient for plants. Dicot plants respond to insufficient B supply by altering root architecture and root hair growth. How root systems of rather low‐B demanding monocot species such as maize (Zea mays L.) respond to B deficiency in terra has not been experimentally resolved, yet.
Manuela Désirée Bienert, Astrid Junker, Michael Melzer, Thomas Altmann, Nicolaus von Wirén, Gerd Patrick Bienert   +5 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Plasma p‐tau181 as a Marker of Conversion to Alzheimer's Disease Dementia and Worsening in Cognitive Functions in Subjective Cognitive Decline and Mild Cognitive Impairment: A Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Plasma p‐tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p‐tau181 in predicting conversion to AD dementia and worsening in cognition in mild cognitive impairment (MCI) and subjective cognitive decline (SCD).
Giulia Giacomucci, Assunta Ingannato, Chiara Crucitti, Silvia Bagnoli, Elisa Marcantelli, Sonia Padiglioni, Valentina Moschini, Carmen Morinelli, Laura Falsini, Sandro Sorbi, Valentina Berti, Benedetta Nacmias, Valentina Bessi   +12 more
wiley   +1 more source

Development of SiC Nanocomposites Using Direct Ink Writing Process

Advanced Engineering Materials, EarlyView.
Herein, feedstock inks containing polycarbosilane and various concentrations of SiC nanoparticles (SiCnp) are investigated for fabricating ceramic matrix composites using a DIW 3D printing process. Characterization results from physical measurement, microstructure analysis, and thermal and flexural testing suggested that high‐performance CMC samples ...
Jinchen Han, Israa Eltahir Ali Elfaki, Luke Weston, Chenggang Chen, Donald A. Klosterman, Li Cao   +5 more
wiley   +1 more source

Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection

Advanced Functional Materials, EarlyView.
Microgels consisting of swollen polyacrylic acid polymer networks, impregnated with nanodiamonds provide protection from ultraviolet (UV) radiation harmful to human health. Nanodiamonds enable UV blockage and control of the rheology (flow) and lubrication (skin‐feel) of these microgel‐skincare‐mimics.
Pallav K. Jani, Sarvesh A. Nadkarni, Katherine J. Ernst, Barbara V. Farias, Chloe G. Hincher, Oluwatobi A. Ojuade, Yug C. Saraswat, Prottasha Sarker, Donald O. Freytes, Lilian C. Hsiao, Saad A. Khan   +10 more
wiley   +1 more source

Differential Compartmentalization of Enzymatic Reactions for Lactate Signaling Across Protocells

Advanced Functional Materials, EarlyView.
Two populations of protocells consisting of giant unilamellar vesicles containing active species and distinct artificial organelles are competent of collective behavior by mimicking production, intercellular communication, and detection of the bioinspired signal molecule lactate. Enzymatic cascade reactions within artificial organelles demonstrate that
Arianna Balestri, Xinan Huang, Emanuel Lörtscher, Cora‐Ann Schoenenberger, Cornelia G. Palivan   +4 more
wiley   +1 more source

Interface‐Induced Stability of Nontrivial Topological Spin Textures: Unveiling Room‐Temperature Hopfions and Skyrmions

Advanced Materials, EarlyView.
The first room‐temperature, zero‐field observation of stable skyrmion–hopfion spin textures in EuS─Bi2Se3─EuS trilayers is reported. Combining Lorentz TEM imaging and micromagnetic modeling, the authors unveil how interfacial Dzyaloshinskii–Moriya interaction and geometric confinement stabilize these multidimensional topological states.
Ferhat Katmis, Valeria Lauter, Rawana Yagan, Iuri S. Brandt, Arash M. Cheghabouri, Hua Zhou, John W. Freeland, Clodoaldo I. L. de Araujo, Michelle E. Jamer, Don Heiman, Mehmet C. Onbasli, Jagadeesh S. Moodera   +11 more
wiley   +1 more source

The Role of Optical Centers in Neodymium‐Doped Calcium Fluoride: Optical Tagging and Nanothermometry in the Second Biological Window

Advanced Optical Materials, EarlyView.
Tuning excitation by only 6 nm unveils three distinct optical centres in CaF2:Nd3⁺,Y3⁺, each with unique spectral fingerprints. Some exhibit properties ideal for precise nanoscale temperature sensing. Abstract Nd3+ has been proposed for nanothermometry in biological media, as both its emission and excitation wavelengths fall within the regions of low ...
Pablo Camarero, Rosalía López‐Méndez, Diego Lecumberri Díez, Patricia Haro‐González, Eugenio Cantelar, Marta Quintanilla   +5 more
wiley   +1 more source