Results 31 to 40 of about 408 (144)
Recyclable All‐in‐One Organo‐Photo‐Auxiliaries Enabling (sp3)C−(sp3)C Coupling Reactions with Diverse Functionalities
Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.Abstract
Photochemical C−C coupling reactions can be tailored to industrial chemical processes and preparations of pharmaceuticals. Recent approaches in this area are limited to using precious transition metal coordination complexes that facilitate light absorption and redox processes with benchtop chemicals. Herein, we propose a paradigm that involves Samjhana Maharjan, Ravi Kishore Dakoju, Bella Albano, Pamela A. Ondiek, Joseph M. O'Shea, Angel G. Cosme‐Hernandez, Donald Wink, Barry C. Pemberton, Steven A. Lopez, A. Jean‐Luc Ayitou +9 morewiley +1 more sourceCathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis
Advanced Science, EarlyView.CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.Mengting Chen, Xiaoxiao Meng, Yong Zhu, Dapeng Wang, Mengmeng Wang, Ziyuan Wang, Xue Tian, Jiaxiang Zhang, Zhiying Yue, Zhengfeng Yang, Ruilan Wang +10 morewiley +1 more sourceEnhancing Grasping Function with a Thermoresponsive Ionogel Adhesive Glove for Patients with Rheumatic Diseases
Advanced Science, EarlyView.This study presents a novel portable grasp‐assist glove, weighing only 47 g. The glove integrates smart adhesive pads and a hands‐free control interface based on IMU, designed to aid rheumatic patients with impaired hand function. The system enables switchable adhesion with independent control and detection of user release intent.Shiqiang Wang, Shiqing Liu, Jingfeng Zhang, Zhouyang Yu, Yifan Shao, Cong Zhao, Jiahong Ma, Xin Fu, Mengqi Yang, Lie Chen, Mingjie Liu, Li Wen +11 morewiley +1 more sourceBiological Insights From 108 Schizophrenia-Associated Genetic Loci
Nature, 2014 Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies.S. Ripke, B. Neale, A. Corvin, J. Walters, Kai-How Farh, P. Holmans, Phil H. Lee, B. Bulik-Sullivan, D. Collier, Hailiang Huang, T. Pers, I. Agartz, E. Agerbo, M. Albus, Madeline Alexander, F. Amin, S. Bacanu, M. Begemann, R. Belliveau, J. Bene, Sarah L Bergen, Elizabeth Bevilacqua, T. Bigdeli, D. Black, R. Bruggeman, N. Buccola, R. Buckner, W. Byerley, W. Cahn, Guiqing Cai, D. Campion, R. Cantor, V. Carr, N. Carrera, S. Catts, K. Chambert, R. Chan, Ronald Y. L. Chan, E. Chen, Wei Cheng, E. Cheung, S. Chong, C. Cloninger, D. Cohen, Nadine Cohen, P. Cormican, N. Craddock, J. Crowley, D. Curtis, M. Davidson, K. Davis, F. Degenhardt, J. Del Favero, D. Demontis, D. Dikeos, T. Dinan, S. Djurovic, G. Donohoe, Elodie Drapeau, J. Duan, F. Dudbridge, N. Durmishi, P. Eichhammer, J. Eriksson, V. Escott-Price, L. Essioux, A. Fanous, M. Farrell, J. Frank, L. Franke, R. Freedman, N. Freimer, M. Friedl, J. Friedman, M. Fromer, G. Genovese, L. Georgieva, I. Giegling, P. Giusti-Rodríguez, S. Godard, J. Goldstein, V. Golimbet, S. Gopal, J. Gratten, L. de Haan, C. Hammer, M. Hamshere, M. Hansen, T. Hansen, V. Haroutunian, A. Hartmann, F. Henskens, S. Herms, J. Hirschhorn, P. Hoffmann, A. Hofman, M. Hollegaard, D. Hougaard, M. Ikeda, I. Joa, A. Julià, R. Kahn, L. Kalaydjieva, Sena Karachanak-Yankova, J. Karjalainen, D. Kavanagh, M. Keller, J. Kennedy, A. Khrunin, Yunjung Kim, J. Kloviņš, J. Knowles, B. Konte, V. Kučinskas, Z. Kučinskienė, Hana Kuzelova-Ptackova, A. Kähler, C. Laurent, Jimmy Lee, S. H. Lee, S. Legge, B. Lerer, Miaoxin Li, Tao Li, K. Liang, J. Lieberman, S. Limborska, C. Loughland, J. Lubiński, J. Lönnqvist, M. Macek, P. Magnusson, B. Maher, W. Maier, J. Mallet, S. Marsal, M. Mattheisen, M. Mattingsdal, R. McCarley, C. Mcdonald, A. McIntosh, S. Meier, C. Meijer, B. Melegh, I. Melle, R. Mesholam-Gately, A. Metspalu, P. Michie, L. Milani, V. Milanova, Y. Mokrab, D. Morris, O. Mors, K. Murphy, R. Murray, I. Myin‐Germeys, B. Müller-Myhsok, M. Nelis, I. Nenadić, D. Nertney, G. Nestadt, K. Nicodemus, L. Nikitina-Zake, L. Nisenbaum, Annelie Nordin, E. O'callaghan, C. O’Dushlaine, F. O’Neill, Sang-Yun Oh, A. Olincy, L. Olsen, J. van os, C. Pantelis, G. Papadimitriou, S. Papiol, E. Parkhomenko, M. Pato, T. Paunio, M. Pejović-Milovančević, D. Perkins, O. Pietiläinen, J. Pimm, A. Pocklington, J. Powell, A. Price, A. Pulver, S. Purcell, D. Quested, H. Rasmussen, A. Reichenberg, M. Reimers, A. Richards, J. Roffman, P. Roussos, D. Ruderfer, V. Salomaa, A. Sanders, U. Schall, C. Schubert, T. Schulze, S. Schwab, E. Scolnick, R. Scott, L. Seidman, Jianxin Shi, E. Sigurdsson, T. Silagadze, J. Silverman, K. Sim, P. Slominsky, J. Smoller, H. So, C. Spencer, E. Stahl, H. Stefánsson, S. Steinberg, E. Stogmann, R. Straub, E. Strengman, J. Strohmaier, T. Stroup, M. Subramaniam, J. Suvisaari, D. Svrakic, J. Szatkiewicz, E. Söderman, S. Thirumalai, D. Toncheva, S. Tosato, J. Veijola, J. Waddington, D. Walsh, Dai Wang, Qiang Wang, B. Webb, M. Weiser, D. Wildenauer, N. Williams, Stephanie Williams, S. Witt, A. Wolen, Emily H. M. Wong, B. Wormley, H. Xi, C. Zai, Xue-bin Zheng, F. Zimprich, N. Wray, K. Stefánsson, P. Visscher, R. Adolfsson, O. Andreassen, D. Blackwood, E. Bramon, J. Buxbaum, A. Børglum, S. Cichon, A. Darvasi, E. Domenici, H. Ehrenreich, T. Esko, P. Gejman, M. Gill, H. Gurling, C. Hultman, N. Iwata, A. Jablensky, E. Jönsson, K. Kendler, G. Kirov, J. Knight, T. Lencz, D. Levinson, Qingqin S. Li, Jianjun Liu, A. Malhotra, S. Mccarroll, A. McQuillin, J. Moran, P. Mortensen, B. Mowry, M. Nöthen, R. Ophoff, M. Owen, A. Palotie, C. Pato, T. Petryshen, D. Posthuma, M. Rietschel, B. Riley, D. Rujescu, P. Sham, P. Sklar, D. St. Clair, D. Weinberger, J. Wendland, T. Werge, M. Daly, P. Sullivan, M. O’Donovan +299 moresemanticscholar +1 more sourceA Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility
Advanced Science, EarlyView.This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.Dong Yan, Jie Huang, Fengqi Tian, Haidong Shu, Han Chen, Qian Peng, Hongwei Wu, Jianlong Zhao, Anireddy S. N. Reddy, Gang Li, Yuanchao Wang, Suomeng Dong +11 morewiley +1 more sourceDON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy
Advanced Science, EarlyView.This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...Xin Yang, Xiaoshuang Niu, Ye Su, Xiaoyun Ye, Wanqiong Li, Wenxuan Zeng, Xin Zhao, Zhuoying He, Qingyu Dong, Xiuman Zhou, Xinghua Sui, Guanyu Chen, Yanfeng Gao, Juan Liu +13 morewiley +1 more sourceDiscovery to Engineering of Mycotoxin Deoxynivalenol Degrading Enzymes Based on the Specialized Glyoxalase I
Advanced Science, EarlyView.Deoxynivalenol (DON), a prevalent food mycotoxin, is an important risk factor in global food safety. A molecular phylogeny‐guided engineering approach is devised to repurpose specialized glyoxalase I (SPG) as a DON deactivator. Engineered SPG variants demonstrate superior stability and are highly capable of converting DON into less toxic products ...Seung Hee Lee, Song Lim Ham, Kyoungmi Oh, Hyojin Park, Young‐Seo Kang, Tae‐Joo Yang, Taekyung Kim, Jonghwan Kim, Gyu Sung Lee, Min‐Jeong Lee, Jin‐Byung Park, Chung Sub Kim, Nam Yoon Kim +12 morewiley +1 more sourceAn Ultrathin and Lightweight Soft Inflatable Actuator for Natural Tactile Sensory Feedback
Advanced Intelligent Systems, EarlyView.A lightweight, ultrathin soft actuator mimics natural touch by delivering strong, multimodal haptic feedback through pressure and vibration. Tested on both able‐bodied individuals and amputees, it achieves high sensory precision in a compact form. Its simplicity, power, and adaptability hint at transformative applications in prosthetics, immersive ...Hanna Scherer, Francesco Iberite, Giulia Caserta, Nicolo Boccardo, Jacopo Carpaneto, Emanuele Gruppioni, Silvestro Micera, Tommaso Proietti +7 morewiley +1 more source