Results 31 to 40 of about 408 (144)

Reducing Personalization Time and Energy Cost While Walking Outdoors with a Portable Exosuit

open access: yesAdvanced Robotics Research, EarlyView.
Rapid Real‐World Optimization! An AF‐based human‐in‐the‐loop optimization strategy rapidly personalizes a portable hip extension exosuit for incline walking. Real‐time Bayesian optimization of assistive force significantly reduces metabolic energy—up to 16.2%—while converging in just 3 min 24 s.
Kimoon Nam   +7 more
wiley   +1 more source

Recyclable All‐in‐One Organo‐Photo‐Auxiliaries Enabling (sp3)C−(sp3)C Coupling Reactions with Diverse Functionalities

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract Photochemical C−C coupling reactions can be tailored to industrial chemical processes and preparations of pharmaceuticals. Recent approaches in this area are limited to using precious transition metal coordination complexes that facilitate light absorption and redox processes with benchtop chemicals. Herein, we propose a paradigm that involves
Samjhana Maharjan   +9 more
wiley   +1 more source

Cathepsin K Aggravates Pulmonary Fibrosis Through Promoting Fibroblast Glutamine Metabolism and Collagen Synthesis

open access: yesAdvanced Science, EarlyView.
CTSK plays a critical role in pulmonary fibrosis. Excessive CTSK accumulation interacts with SNX9 to enhance TGF‐β1‐induced SMAD3 activation and GLS1 expression in fibroblasts, driving glutamine metabolism for collagen biosynthesis and exacerbating pulmonary fibrosis.
Mengting Chen   +10 more
wiley   +1 more source

Enhancing Grasping Function with a Thermoresponsive Ionogel Adhesive Glove for Patients with Rheumatic Diseases

open access: yesAdvanced Science, EarlyView.
This study presents a novel portable grasp‐assist glove, weighing only 47 g. The glove integrates smart adhesive pads and a hands‐free control interface based on IMU, designed to aid rheumatic patients with impaired hand function. The system enables switchable adhesion with independent control and detection of user release intent.
Shiqiang Wang   +11 more
wiley   +1 more source

Biological Insights From 108 Schizophrenia-Associated Genetic Loci

open access: yesNature, 2014
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies.
S. Ripke   +299 more
semanticscholar   +1 more source

A Phase‐Separated SR Protein Reprograms Host Pre‐mRNA Splicing to Enhance Disease Susceptibility

open access: yesAdvanced Science, EarlyView.
This study identifies SR30, a splicing factor, as a negative regulator of tomato immunity. During Phytophthora infestans infection, the elevated SR30 forms nuclear condensates to suppress the alternative splicing (AS) of defense‐related genes in a phase separation manner.
Dong Yan   +11 more
wiley   +1 more source

DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy

open access: yesAdvanced Science, EarlyView.
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang   +13 more
wiley   +1 more source

Discovery to Engineering of Mycotoxin Deoxynivalenol Degrading Enzymes Based on the Specialized Glyoxalase I

open access: yesAdvanced Science, EarlyView.
Deoxynivalenol (DON), a prevalent food mycotoxin, is an important risk factor in global food safety. A molecular phylogeny‐guided engineering approach is devised to repurpose specialized glyoxalase I (SPG) as a DON deactivator. Engineered SPG variants demonstrate superior stability and are highly capable of converting DON into less toxic products ...
Seung Hee Lee   +12 more
wiley   +1 more source

Configuration and Charge Dynamics of Defect‐Cluster‐Dipoles in CaTiO3 for Enhanced Permittivity

open access: yesAdvanced Electronic Materials, EarlyView.
In La‐doped CaTiO3, the clustering of La ion and Ca vacancies is clearly observed and the configuration of such defect‐cluster is validated. Combining photoelctronic and dielectric spectroscopy enables the dielectric relaxation process with the charge transfer routes.
Jian Wang   +4 more
wiley   +1 more source

An Ultrathin and Lightweight Soft Inflatable Actuator for Natural Tactile Sensory Feedback

open access: yesAdvanced Intelligent Systems, EarlyView.
A lightweight, ultrathin soft actuator mimics natural touch by delivering strong, multimodal haptic feedback through pressure and vibration. Tested on both able‐bodied individuals and amputees, it achieves high sensory precision in a compact form. Its simplicity, power, and adaptability hint at transformative applications in prosthetics, immersive ...
Hanna Scherer   +7 more
wiley   +1 more source

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