Results 41 to 50 of about 113 (113)

Emerging roles of BET proteins in transcription and co‐transcriptional RNA processing

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
Roles of BET proteins in RNA polymerase II transcription and co‐transcriptional RNA processing. Abstract Transcription by RNA polymerase II (Pol II) gives rise to all nuclear protein‐coding and a large set of non‐coding RNAs, and is strictly regulated and coordinated with RNA processing.
Nicole Eischer, Mirjam Arnold, Andreas Mayer   +2 more
wiley   +1 more source

A Cytotoxic Indazole‐based Gold(III) Carboxamide Pincer Complex Targeting DNA Through Dual Binding Modes of Groove Binding and Alkylation

Chemistry – A European Journal, EarlyView.
Toward new gold(III) anticancer agents. Herein, we report on an indazole‐based gold(III) carboxamide pincer complex exhibiting significant cytotoxicity, likely mediated through dual interactions with DNA. Mechanistic investigations suggest that the complex binds to the DNA and forms specific interactions with nucleotide bases.
Rufaro Razuwika, Sheldon Sookai, Ruth Aronson, Mandeep Kaur, Orde Q. Munro   +4 more
wiley   +1 more source

Understanding the Drivers of Coastal Flood Exposure and Risk From 1860 to 2100

Earth's Future, Volume 10, Issue 12, December 2022., 2022
Abstract Global coastal flood exposure (population and assets) has been growing since the beginning of the industrial age and is likely to continue to grow through 21st century. Three main drivers are responsible: (a) climate‐related mean sea‐level change, (b) vertical land movement contributing to relative sea‐level rise, and (c) socio‐economic ...
Daniel Lincke, Jochen Hinkel, Matthias Mengel, Robert J. Nicholls   +3 more
wiley   +1 more source

Study on the effect of co‐plasticization of post‐industrial starch for high‐impact thermoplastic starch development

The Canadian Journal of Chemical Engineering, EarlyView.
High‐impact thermoplastic starch blends through the co‐plasticization methodology. Abstract This study analyzed the effect of employing plasticized or co‐plasticized post‐industrial starch in developing PBAT‐based thermoplastic starch (TPS) blends. In this work, the post‐industrial wheat starch was co‐plasticized with glycerol‐urea, glycerol‐citric ...
Aarsha Surendren, Amar K. Mohanty, Loong‐Tak Lim, Qiang Liu, Bassim Abbassi, Manjusri Misra   +5 more
wiley   +1 more source

NEFTSec: Networked federation testbed for cyber‐physical security of smart grid: Architecture, applications, and evaluation

IET Cyber-Physical Systems: Theory &Applications, Volume 7, Issue 4, Page 197-211, December 2022., 2022
Abstract As today's power grid is evolving into a densely interconnected cyber‐physical system (CPS), a high fidelity and multifaceted testbed environment is needed to perform cybersecurity experiments in a realistic grid environment. Traditional standalone CPS testbeds lack the ability to emulate complex cyber‐physical interdependencies between ...
Vivek Kumar Singh, Manimaran Govindarasu, Donald Porschet, Edward Shaffer, Morris Berman   +4 more
wiley   +1 more source

A Novel Two‐Part Mixture Model for the Incidence and Time Course of Cytokine Release Syndrome After Elranatamab Dosing in Multiple Myeloma Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytokine release syndrome (CRS) is a common, acute adverse event associated with T‐cell redirecting therapies such as bispecific antibodies (BsAbs). The nature of CRS events data makes it challenging to capture an unbiased exposure–response relationship with commonly used models.
Donald Irby, Jennifer Hibma, Mohamed Elmeliegy, Diane Wang, Erik Vandendries, Kamrine Poels, Blerta Shtylla, Jason H. Williams   +7 more
wiley   +1 more source

Wanted: A name for a commonly used trigonometry function

The Journal of Engineering, Volume 2022, Issue 12, Page 1143-1148, December 2022., 2022
Abstract Except in trivial cases, an unknown angle is always extracted from a knowledge of its sine and cosine. These two numbers determine the angle unambiguously; and yet no universally accepted notation expresses that angle as a function of those numbers in a single statement. Some authors use “atan2” for this purpose.
Don Koks
wiley   +1 more source

Effects of elevated ground temperatures on properties of cement grouts for deep rock grouting

Deep Underground Science and Engineering, EarlyView.
When the temperature is up to 35°C, significant improvement in rheological parameters, acceleration of grout setting, and an increase in the rheological time dependence of thick cement grout can occur, but there may be a slight effect on the initial grout flowability and the nature of shear thinning.
Zhipeng Xu, Jianping Sun, Runguo Li, Lei He, Changwu Liu   +4 more
wiley   +1 more source

Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction

ESC Heart Failure, EarlyView.
Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem, Teresa C. Leone, Christopher Petucci, Clarissa Shoffler, Ravindra C. Kodihalli, Tiffany Hidalgo, Cheryl Tow‐Keogh, Jessica Mancuso, Iphigenia Tzameli, Donald Bennett, John D. Groarke, Rachel J. Roth Flach, Daniel J. Rader, Daniel P. Kelly   +13 more
wiley   +1 more source

Cardioprotective effects of semaglutide on isolated human ventricular myocardium

European Journal of Heart Failure, EarlyView.
Semaglutide reduces late sodium current (INa) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end‐stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients. Improved Ca storage may underly the enhanced contractility of human cardiomyocytes upon semaglutide.
Thomas Krammer, Maria J. Baier, Philipp Hegner, Tilman Zschiedrich, David Lukas, Matthias Wolf, Christian Le Phu, Vanessa Lutz, Katja Evert, Kostiantyn Kozakov, Jing Li, Andreas Holzamer, Lars S. Maier, Zdenek Provaznik, Donald M. Bers, Stefan Wagner, Julian Mustroph   +16 more
wiley   +1 more source