Results 41 to 50 of about 408 (144)

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel   +2 more
wiley   +1 more source

Culturally Modified Trees and Bark and Wooden Material Culture From Yagara Country, Southeast Queensland, Australia: A Preliminary Overview of Indigenous Biocultural Knowledge

open access: yesArchaeology in Oceania, EarlyView.
ABSTRACT This paper outlines preliminary results from our multimethod research about Culturally Modified Trees (CMTs) and associated bark and wooden material culture in Yagara Country in southeast Queensland. Methods employed include historical source and modern database analysis, archaeological field surveys, semi‐structured interviews with Yagara ...
Kate Greenwood   +3 more
wiley   +1 more source

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium

open access: yesmedRxiv, 2023
F. Rajabli   +270 more
semanticscholar   +1 more source

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

open access: yesThe Lancet, 2021
O. Abani   +499 more
semanticscholar   +1 more source

Expert Perspective: Diagnosis and Treatment of Castleman Disease

open access: yesArthritis &Rheumatology, Accepted Article.
Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen   +2 more
wiley   +1 more source

Loss of TRIM21 drives UVB‐induced systemic inflammation by regulating DNA‐sensing pathways

open access: yesArthritis &Rheumatology, Accepted Article.
Background Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to ultraviolet light B (UVB) driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a ...
Gantsetseg Tumurkhuu   +17 more
wiley   +1 more source

Establishing a 3D Vascularized Tri‐Culture Model of the Human Airways via a Digital Light Processing Bioprinter

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 8, Page 2273-2280, August 2025.
ABSTRACT The rise in chronic lung diseases globally and the corresponding lag in drug discovery in this field highlights the need for In Vitro models closely mimicking In Vivo lung tissue. Efforts to date have largely focused on In Vitro coculture models, often neglecting the pulmonary vasculature's role in lung physiology and lacking perfusability. To
Sakshi Phogat   +3 more
wiley   +1 more source

Thymidine Phosphorylase Inhibitory Potential and Molecular Docking Studies of Secondary Metabolites Isolated From Fernandoa adenophylla (Wall. ex G. Don) Steenis

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT This study investigates the potential of Fernandoa adenophylla, a South American plant, as a reservoir of compounds with thymidine phosphorylase (TP) inhibitory activity. Through a comprehensive approach combining in vitro assays and molecular docking analysis, we isolated and characterized bioactive compounds from F.
Abdur Rauf   +11 more
wiley   +1 more source

Study on the effect of co‐plasticization of post‐industrial starch for high‐impact thermoplastic starch development

open access: yesThe Canadian Journal of Chemical Engineering, EarlyView.
High‐impact thermoplastic starch blends through the co‐plasticization methodology. Abstract This study analyzed the effect of employing plasticized or co‐plasticized post‐industrial starch in developing PBAT‐based thermoplastic starch (TPS) blends. In this work, the post‐industrial wheat starch was co‐plasticized with glycerol‐urea, glycerol‐citric ...
Aarsha Surendren   +5 more
wiley   +1 more source

Taste Profile and Relative Bioavailability of Tovorafenib Powder for Oral Suspension and Food Effect of the Tovorafenib Tablet in Healthy Participants

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract A pediatric‐friendly powder for oral suspension (PfOS) of tovorafenib, a type II RAF inhibitor, was developed for patients with difficulty swallowing tablets. This open‐label, randomized, phase 1 study (QSC205140) evaluated the taste/palatability of PfOS formulations (n = 12), the relative bioavailability of the PfOS versus tablet formulation,
Yang Zhang   +6 more
wiley   +1 more source
medicine
chemistry
computer science
environmental science
environmental chemistry
history
internal medicine
previous   3  4  5  6  7  

Home - About - Disclaimer - Privacy