Results 51 to 60 of about 408 (144)

Constructing a cave sediment stratigraphy for the Dachstein Massif sheds light on landscape evolution (Eastern Alps)

The Depositional Record, EarlyView.
Five large Alpine cave systems on the Dachstein (Austria) were investigated and 35 sediment profiles or outcrops between 860 m a.s.l. and 1945 m a.s.l. were analysed. An altitude‐dependent overall stratigraphy is established and depositional conditions and palaeo‐environments are reconstructed.
Franziska Holzer, Lukas Plan, Susanne Gier   +2 more
wiley   +1 more source

Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction

ESC Heart Failure, EarlyView.
Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem, Teresa C. Leone, Christopher Petucci, Clarissa Shoffler, Ravindra C. Kodihalli, Tiffany Hidalgo, Cheryl Tow‐Keogh, Jessica Mancuso, Iphigenia Tzameli, Donald Bennett, John D. Groarke, Rachel J. Roth Flach, Daniel J. Rader, Daniel P. Kelly   +13 more
wiley   +1 more source

Pre‐admission beta‐blocker therapy and outcomes in cardiogenic shock: Insights from the Altshock‐2 Registry

ESC Heart Failure, EarlyView.
Among 668 with cardiogenic shock included in the multicentre prospective Altshock‐2 registry, 299 patients (44.8%) received pre‐admission beta‐blocker therapy. Previous beta‐blocker therapy influenced the early hemodynamic response to vasoactive drugs, but it was not associated with in‐hospital mortality.
Matteo Pagnesi, Mauro Riccardi, Alice Sacco, Giovanni Tavecchia, Giovanna Viola, Simone Frea, Martina Briani, Letizia Fausta Bertoldi, Maurizio Bertaina, Luciano Potena, Serafina Valente, Marco Marini, Gaetano Maria De Ferrari, Nicoletta D'Ettore, Astrid Cardinale, Rita Camporotondo, Matteo Rota, Guido Tavazzi, Nuccia Morici, Federico Pappalardo, Marco Metra, on behalf of the Altshock‐2 investigators   +21 more
wiley   +1 more source

Cardioprotective effects of semaglutide on isolated human ventricular myocardium

European Journal of Heart Failure, EarlyView.
Semaglutide reduces late sodium current (INa) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end‐stage heart failure with reduced ejection fraction (HFrEF) patients, thereby increasing Ca transients. Improved Ca storage may underly the enhanced contractility of human cardiomyocytes upon semaglutide.
Thomas Krammer, Maria J. Baier, Philipp Hegner, Tilman Zschiedrich, David Lukas, Matthias Wolf, Christian Le Phu, Vanessa Lutz, Katja Evert, Kostiantyn Kozakov, Jing Li, Andreas Holzamer, Lars S. Maier, Zdenek Provaznik, Donald M. Bers, Stefan Wagner, Julian Mustroph   +16 more
wiley   +1 more source

Lung ultrasound and mortality in a cardiogenic shock population: A prospective registry‐based analysis

European Journal of Heart Failure, EarlyView.
Lung ultrasound (LUS) and mortality in cardiogenic shock (CS) patients. Abstract Aims Lung ultrasound (LUS) is a widely used technique to assess de‐aeration in critically ill patients with respiratory failure. There is paucity of data on LUS in cardiogenic shock (CS).
Guido Tavazzi, Costanza Natalia Julia Colombo, Matteo Pagnesi, Maurizio Bertaina, Andrea Montisci, Simone Frea, Marco Marini, Martina Briani, Lisa Patrini, Francesca Rossi, Letizia Bertoldi, Giulia Maj, Giovanna Viola, Carlotta Sorini Dini, Serafina Valente, Gaetano Maria De Ferrari, Nuccia Morici, Federico Pappalardo, Alice Sacco, on behalf of the Altshock Group   +19 more
wiley   +1 more source

Kidney injury in patients with heart failure‐related cardiogenic shock: Results from an international, multicentre cohort study

European Journal of Heart Failure, EarlyView.
Kidney injury in heart failure‐related cardiogenic shock. AKI, acute kidney injury; CI, confidence interval; eCPR, extracorporeal cardiopulmonary resuscitation; eGFR, estimated glomerular filtration rate; HR, hazard ratio; OR, odds ratio; VA‐ECMO, veno‐arterial extracorporeal membrane oxygenation.
Jonas Sundermeyer, Caroline Kellner, Benedikt N. Beer, Lisa Besch, Angela Dettling, Letizia Fausta Bertoldi, Stefan Blankenberg, Jeroen Dauw, Dennis Eckner, Ingo Eitel, Tobias Graf, Patrick Horn, Joanna Jozwiak‐Nozdrzykowska, Paulus Kirchhof, Stefan Kluge, Axel Linke, Ulf Landmesser, Enzo Lüsebrink, Nicolas Majunke, Norman Mangner, Sven Möbius Winkler, Peter Nordbeck, Martin Orban, Federico Pappalardo, Matthias Pauschinger, Michal Pazdernik, Alastair Proudfoot, Matthew Kelham, Tienush Rassaf, Hermann Reichenspurner, Clemens Scherer, P. Christian Schulze, Robert H.G. Schwinger, Carsten Skurk, Marek Sramko, Guido Tavazzi, Holger Thiele, Luca Villanova, Nuccia Morici, Ephraim B. Winzer, Dirk Westermann, Benedikt Schrage   +41 more
wiley   +1 more source

The Dual Pathways to Masculinity Threats: The Roles of Social Role Incongruity and Social Connection in Masculine Identity Maintenance Among Gay and Straight Men

European Journal of Social Psychology, EarlyView.
ABSTRACT Humans are hardwired to seek out social connections, as well as monitor for warning signs that their belonging may be at risk. Social identities provide a mechanism through which to monitor belonging, shaping how people understand and see themselves, as well as how they are perceived by others. This large qualitative study (n = 203) presents a
Veronica M. Lamarche, Alyssa Croft, Ciara Atkinson   +2 more
wiley   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of the Immune Response to COVID‐19 and Tuberculosis Coinfection

Exploration, EarlyView.
Understanding the immunological basis for severe outcomes in COVID‐19/Tuberculosis coinfection is critical. Our single‐cell analysis identifies key drivers: profound lymphocyte loss through combined apoptosis and altered trafficking, excessive S100 protein‐mediated inflammation contributing to cytokine storms, and systemic immune dysfunction ...
Yi Wang, Maike Zheng, Yun Zhang, Yu Xue, Sibo Long, Chaohong Wang, Qing Sun, Jun Yan, Yiheng Shi, Bin Yang, Shang Ma, Tiantian Zhang, Lei Cao, Yan Chen, Wenfu Ju, Jing Zhang, Yan Zhao, Mengqiu Gao, Laurence Don Wai Luu, Xinting Yang, Guirong Wang   +20 more
wiley   +1 more source

SynCom‐mediated herbicide degradation activates microbial carbon metabolism in soils

iMeta, EarlyView.
Extensive herbicide residues in the black soil of northeastern China are considered a significant agricultural pollution threat, yet effective bioremediation of this complex and persistent mixture remains a challenge. We provided an herbicide degradation and ecosystem regulation model of SynCom in soil. We also demonstrated the effectiveness of SynCom “
Yuxiao Zhang, Jack A. Gilbert, Xuan Liu, Li Nie, Xiyuan Xu, Guifeng Gao, Lihui Lyu, Yuying Ma, Kunkun Fan, Teng Yang, Yumeng Zhang, Jiabao Zhang, Haiyan Chu   +12 more
wiley   +1 more source