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Results 31 to 40 of about 5,638,603 (255)

ÐÐÐ¢Ð˜ÐœÐ˜ÐšÐ ÐžÐ‘ÐÐ Ð Ð•Ð—Ð˜Ð¡Ð¢Ð•ÐÐ¦Ð˜ÐˆÐ (ÐÐœÐ ) Ð’Ðž Ð•Ð’Ð ÐžÐŸÐ Ð˜ Ð‘ÐÐ›ÐšÐÐÐ¡ÐšÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ – ÐŸÐ Ð•Ð“Ð›Ð•Ð” ÐÐ Ð¡Ð•Ð“ÐÐ¨ÐÐÐ¢Ð Ð¡ÐžÐ¡Ð¢ÐžÐˆÐ‘Ð [PDF]

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source

ÐŸÐ Ð˜Ð¡Ð¢ÐÐŸ Ð”Ðž Ð‘Ð•Ð—Ð‘Ð•Ð”ÐÐ Ð’ÐžÐ”Ð Ð—Ð ÐŸÐ˜Ð•ÐŠÐ• Ð’Ðž Ð¡Ð•Ð’Ð•Ð ÐžÐ˜Ð¡Ð¢ÐžÐ§ÐÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ ÐÐ Ð Ð•ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ ÐœÐÐšÐ•Ð”ÐžÐÐ˜ÐˆÐ- Ð Ð•Ð¢Ð ÐžÐ¡ÐŸÐ•ÐšÐ¢Ð˜Ð’ÐÐ ÐÐÐÐ›Ð˜Ð—Ð [PDF]

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source

, 2017
Epidemiological data indicates that thyroid carcinoma (TC) is the most frequent endocrinological tumors, participating with around 1% from all malignomas.
Ð¢Ñ€Ð¸Ð¿ÑƒÐ½Ð¾ÑÐºÐ¸ (Tripunoski), Ð¢Ð¾Ð½Ð¸ (Toni) +3 more
core +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart +2 more
wiley +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source

, 2017
Acute appendicitis is very common acute surgical condition in childhood that requires quick and safe treatment with least possible complications.
Ð¡Ð¸Ð¼ÐµÐ¾Ð½Ð¾Ð², Ð Ð¸ÑÑ‚Ð¾
core +1 more source

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