Results 161 to 170 of about 6,329,447 (296)

ИÑкуÑÑтво, показ, влаÑть. Фелипе IV и иконографичеÑÐºÐ°Ñ Ð¿Ñ€Ð¾Ð³Ñ€Ð°Ð¼Ð¼Ð° Зала ЦарÑтва дворца БуÑн-Ретиро. ÐтлантичеÑкий контекÑÑ‚

open access: yes, 2019
The Palace of the Buen Retiro was constructed between 1630 and 1635 in the suburbs of Madrid as place of rest for Philip IV and his court. One of its main rooms was called Salon de Reinos, a place that hosted an iconographic program that, besides the ...
García Sánchez , Laura
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

ПолициÑтична бубрежна болеÑÑ‚ - приказ на пациент

open access: yes, 2016
Was to present disease, over a patient review of policystic kidney disease, that need hospitalization many times – because of complications that follow it (uroinfection, calculosis, anaemia, chronical kidney insufficiency, hypertension, and cistes crack ...
Поленаковиќ (Polenakovikj), Момир (Momir)   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

d-amino acids restrain macrophage IL-1β release through gasdermin D acetylation. [PDF]

open access: yesSci Adv
Wu Z   +8 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

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