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Results 111 to 120 of about 5,872,567 (301)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source

, 2017
Acute appendicitis is very common acute surgical condition in childhood that requires quick and safe treatment with least possible complications.
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core +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source

Two classes of ideals determined by integer-valued polynomials [PDF]

Rendiconti di Matematica e delle Sue Applicazioni, 1996
If D is a domain with quotient field K, let Int(D) = {f(X) ∈ K[X] | f(d) ∈ D for every d ∈ D} be the ring of integer-valued polynomials over D. It is well known that the binomial polynomials GX n H = X(X−1)...(X−n+1) n!
P.J. CAHEN, S.T. CHAPMAN, K. ROEGNER, W.W. SMITH +3 more
doaj

(K − 1)-Kernels In Strong K-Transitive Digraphs

Discussiones Mathematicae Graph Theory, 2015
Let D = (V (D),A(D)) be a digraph and k ≥ 2 be an integer. A subset N of V (D) is k-independent if for every pair of vertices u, v ∈ N, we have d(u, v) ≥ k; it is l-absorbent if for every u ∈ V (D) − N, there exists v ∈ N such that d(u, v) ≤ l.
Wang Ruixia
doaj +1 more source

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, 2020
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openalex +1 more source

, 2018
Congenital anomalies of the kidney and urinary tract- CAKUT are common childhood pathology accounting for 20-30% of all perinatally detected congenital anomalies. The importance of CAKUT is the risk they represent to kidney function deterioration and end-
Ð¢Ð°ÑÐ¸Ñœ (Tasic), Ð’ÐµÐ»Ð¸Ð±Ð¾Ñ€ (Velibor) +6 more
core +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source

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