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Results 71 to 80 of about 5,872,567 (301)

, 2017
The study aims to compare the conventional open technique for treating inguinal hernia versus laparoscopic assisted technique of percutaneous closure of the internal inguinal ring in female children with clinically diagnosed indirect inguinal hernia ...
Ð Ð¸ÑÑ‚ÐµÑÐºÐ¸ (Risteski), Ð¢Ð¾Ð½Ð¸ (Toni) ÐœÐ¸Ñ€Ñ‡Ðµ (Mirce) +4 more
core +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source

ÐœÐ•ÐÐ•Ð”Ð–ÐœÐ•ÐÐ¢ ÐšÐ£Ð›Ð¬Ð¢Ð£Ð Ð« Ð’ ÐœÐÐ›ÐžÐœ Ð‘Ð˜Ð—ÐÐ•Ð¡Ð• Ð Ð•Ð¡ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ˜ ÐœÐžÐ›Ð”ÐžÐ’Ð

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source

ÐžÐ¡ÐžÐ‘Ð•ÐÐÐžÐ¡Ð¢Ð˜ Ð ÐÐ¡Ð§Ð•Ð¢Ð Ð¡Ð¢ÐžÐ˜ÐœÐžÐ¡Ð¢Ð˜ Ð—Ð•ÐœÐ•Ð›Ð¬ÐÐžÐ“Ðž Ð£Ð§ÐÐ¡Ð¢ÐšÐ Ð”Ð›Ð¯ Ð¡Ð¢Ð ÐžÐ˜Ð¢Ð•Ð›Ð¬Ð¡Ð¢Ð’Ð Ð˜ ÐžÐ‘Ð¡Ð›Ð£Ð–Ð˜Ð’ÐÐÐ˜Ð¯ Ð–Ð˜Ð›ÐžÐ“Ðž Ð”ÐžÐœÐ .

, 2018
The aim of this study was to evaluate the central obesity, which is a main characteristic of Cushing's syndrome (CS), with dual-energy x-ray absorptiometry (DXA) and to determine DXA indexes that precisely differentiate CS from non CS obese women.
Ð¢Ð¾Ð´Ð¾Ñ€Ð¾Ð²ÑÐºÐ° (Todorovska), Ð›Ð¸Ð´Ð¸Ñ˜Ð° (Lidija) +1 more
core +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source

ÐŸÐžÐ”Ð“ÐžÐ¢ÐžÐ’ÐšÐ Ð¡Ð¢Ð£Ð”Ð•ÐÐ¢ÐžÐ’ Ðš ÐŸÐ ÐžÐ¤Ð•Ð¡Ð¡Ð˜ÐžÐÐÐ›Ð¬ÐÐžÐ™ Ð˜ÐÐÐžÐ’ÐÐ¦Ð˜ÐžÐÐÐžÐ™ Ð”Ð•Ð¯Ð¢Ð•Ð›Ð¬ÐÐžÐ¡Ð¢Ð˜ Ð’ Ð ÐÐœÐšÐÐ¥ Ð¡ÐŸÐ•Ð¦Ð˜ÐÐ›Ð¬ÐÐžÐ“Ðž Ð£Ð§Ð•Ð‘ÐÐžÐ“Ðž ÐšÐ£Ð Ð¡Ð

Boundedness of strong maximal functions with respect to non-doubling measures

Journal of Inequalities and Applications, 2016
The main purpose of this paper is to establish a boundedness result for strong maximal functions with respect to certain non-doubling measures in R n $\mathbb{R}^{n}$ . More precisely, let d μ ( x 1 , … , x n ) = d μ 1 ( x 1 ) ⋯ d μ n ( x n ) $d\mu(x_{1},
Wei Ding, LiXin Jiang, YuePing Zhu
doaj +1 more source

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