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Results 101 to 110 of about 9,273,634 (241)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source

Exploring Efimov states in D * D * D * and DD * D * three-body systems

Journal of High Energy Physics
The Efimov effect is an intriguing three-body quantum phenomenon. Searching for Efimov states within the realms of nuclear and hadronic physics presents a challenge due to the inherent inability of natural physical systems to exhibit adjustable two-body ...
Hai-Long Fu +6 more
doaj +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov +2 more
wiley +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn +2 more
wiley +1 more source

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Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source

Measurement of CP asymmetries in B ¯ 0 → D s − D + $$ {\overline{B}}^0\to {D}_s^{-}{D}^{+} $$ and B ¯ s 0 → D s − D − $$ {\overline{B}}_s^0\to {D}_s^{-}{D}^{-} $$ decays

Journal of High Energy Physics
Measurements of the combined CP asymmetries in B ¯ 0 → D s − D + $$ {\overline{B}}^0\to {D}_s^{-}{D}^{+} $$ and B ¯ s 0 → D s − D − $$ {\overline{B}}_s^0\to {D}_s^{-}{D}^{-} $$ decays are made using proton-proton collision data collected by the LHCb ...
The LHCb collaboration +1212 more
doaj +1 more source

, 2016
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core

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source

, 2017
It has been examined the possibility of thyroid tissue as to how as a same antigen influence on blast - transformation, eventually on previously sensitised lymphocytes at thyrotoxicosis patients.The lymphocytes have been separated (taken) from the vein ...
ÐœÐ°Ð»Ð¸Ð½Ð¾Ð²Ð° (Malinova), Ð‰ÑƒÐ±Ð¸Ð½ÐºÐ° (Ljubinka) +1 more
core

astrophysics
b physics