Results 201 to 210 of about 9,273,634 (241)

Layer-specific quantitative analysis of accommodation in the human lens using long-range OCT and machine learning. [PDF]

Eye Vis (Lond)
Soman K, Usman M, Urriza-Arpal R, Gondek G, Karnowski K, Ruminski J, Grulkowski I.   +6 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Bayesian Power-Based Sample Size Determination for Diagnostic Accuracy Studies. [PDF]

Pharm Stat
Shiota S, Horiguchi G, Naito A, Nakata M, Teramukai S.   +4 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

D-enantiomeric β-casein 197 disrupts biofilm-associated infection of MDR <i>Pseudomonas aeruginosa</i> and <i>Acinetobacter baumannii</i> through superior LPS binding and host cell protection. [PDF]

Virulence
Jiang K, Wang W, Lei H, Wang T, Xu L, Yang Y, Zhou R, Lin T, Huang Y.   +8 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Unrevealed oligoresveratrols from <i>Shorea parvifolia</i> root bark as xanthine oxidase inhibitors: isolation, <i>in vitro</i> bioassay, quantum studies and structure-based computational profiling. [PDF]

RSC Adv
Windah ALL, Aminah NS, Kristanti AN, Siswanto I, Hariyanto GF, Budiastanti TA, Takaya Y, Abdjan MI.   +7 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Chromosome-Level Genome Assemblies of <i>Darevskia mixta</i> and <i>Darevskia valentini</i>: A Platform for Studying Parthenogenesis in Caucasian Rock Lizards. [PDF]

Animals (Basel)
Dvorianinova EM, Ivankina EA, Korchagin VI, Vergun AA, Martirosyan IA, Arakelyan MS, Girnyk AE, Dmitriev AA, Ryskov AP.   +8 more
europepmc   +1 more source