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Ð¢Ñ€Ð¸ ÑÐ»ÑƒÑ‡Ð°Ð¸ Ð½Ð° Syndroma Willi Prader Labhardt Ð²Ð¾ Ð´Ð¾ÐµÐ½ÐµÑ‡ÐºÐ° Ð²Ð¾Ð·Ñ€Ð°ÑÑ‚ [PDF]

, 2017
Authors presented three cases of Willi Prader Labhardt Syndroma whose cardinal symptoms are: psychomotor retardation, proportional obesity, hypogenitalism, a small bifrontal circumference, and carp-like mouth.During the pregnancy, children's mothers felt
Ð¡Ð¿Ð¸Ñ€Ð¾Ð²ÑÐºÐ¸, Ð—Ð¾Ñ€Ð°Ð½ +2 more
core +1 more source

Pull-Out Test and the Effects Ð¾f Using Different Types Ð¾f Cements and Upgrading Systems Ð¾n Endodontic Treated Teeth [PDF]

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski +2 more
wiley +1 more source

ÐÐÐ¢Ð˜ÐœÐ˜ÐšÐ ÐžÐ‘ÐÐ Ð Ð•Ð—Ð˜Ð¡Ð¢Ð•ÐÐ¦Ð˜ÐˆÐ (ÐÐœÐ ) Ð’Ðž Ð•Ð’Ð ÐžÐŸÐ Ð˜ Ð‘ÐÐ›ÐšÐÐÐ¡ÐšÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ – ÐŸÐ Ð•Ð“Ð›Ð•Ð” ÐÐ Ð¡Ð•Ð“ÐÐ¨ÐÐÐ¢Ð Ð¡ÐžÐ¡Ð¢ÐžÐˆÐ‘Ð [PDF]

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source

Boundedness of strong maximal functions with respect to non-doubling measures

Journal of Inequalities and Applications, 2016
The main purpose of this paper is to establish a boundedness result for strong maximal functions with respect to certain non-doubling measures in R n $\mathbb{R}^{n}$ . More precisely, let d μ ( x 1 , … , x n ) = d μ 1 ( x 1 ) ⋯ d μ n ( x n ) $d\mu(x_{1},
Wei Ding, LiXin Jiang, YuePing Zhu
doaj +1 more source

A Historical Writing Apprenticeship for Adolescents: Integrating Disciplinary Learning With Cognitive Strategies [PDF]

, 2016
This study explored the extent to which an 18â day history and writing curriculum intervention, taught over the course of one year, helped culturally and academically diverse adolescents achieve important disciplinary literacy learning in history ...
Croninger, Robert +5 more
core +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source

computer science
process computing
identification biology

product mathematics
set abstract data type
selection genetic algorithm

natural archaeology
term time
context archaeology