Results 111 to 120 of about 6,151,732 (298)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Зголемени вредности на IL-8 во ран втор триместар и нивната поврзаност со предвремено раѓање

, 2020
Цитокините (IL-1, IL-6, IL-8, TNF- Alfa) се од исклучително значење во бременоста и тие се продуцираат од страна на постелката во амнионската течност и
Aleksandar Petlickovski, Iva Malahova- Gjoreska, Ivi Kaev, Katerina Nikoloska   +3 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The Distance Matrices of Some Graphs Related to Wheel Graphs

Journal of Applied Mathematics, 2013
Let D denote the distance matrix of a connected graph G. The inertia of D is the triple of integers (n+(D), n0(D), n-(D)), where n+(D), n0(D), and n-(D) denote the number of positive, 0, and negative eigenvalues of D, respectively.
Xiaoling Zhang, Chengyuan Song
doaj   +1 more source

Kлинички тек и иÑход кај пациенти Ñо рано дијагноÑтицирани конгенитални малформации на бубрезите и уринарниот тракт [PDF]

, 2018
Congenital anomalies of the kidney and urinary tract- CAKUT are common childhood pathology accounting for 20-30% of all perinatally detected congenital anomalies. The importance of CAKUT is the risk they represent to kidney function deterioration and end-
ТаÑиќ (Tasic), Велибор (Velibor), ÐлулоÑка (Aluloska), Ðаташа (Natasha), ПалчевÑка (Palchevska), Снежана (Snezhana), ПапазовÑка-ЧерепналковÑки (Papazovska-Cherepnalkovski), Ðнет (Anet), Китева-ТренчевÑка (Kiteva-Trenchevska), Гордана (Gordana), КировÑки (Kirovski), Илија (Ilija), БицевÑка-МанџуковÑка (Bicevska-Mandzukovska), ХриÑтина (Hristina)   +6 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

ЛапароÑкопÑка апендектомија кај деца во Република Македонија [PDF]

, 2017
Acute appendicitis is very common acute surgical condition in childhood that  requires quick and safe treatment with least possible complications.
Симеонов, РиÑто
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source