Results 121 to 130 of about 6,245,476 (298)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Инциденција и преваленција на тироиден карцином во Република Маке- донија (1999-2010) [PDF]

, 2017
Epidemiological data indicates that  thyroid carcinoma (TC)  is the most frequent endocrinological tumors, participating with around 1%  from all malignomas.
ТрипуноÑки (Tripunoski), Тони (Toni), Маказлиева (Makazlieva), Тања (Tanja), МајÑторов (Majstorov), Венјамин (Venjamin), ВаÑкова (Vaskova), Оливија (Olivija)   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

restauration de l'Église Notre-Dame de la Candelaria de Quinterquén, île de Caucachué, Chiloé, Chili [PDF]

, 2019
The following article shows the path of a work team in addressing a process of heritage restoration with a community integration approach, taking up the tradition of minga as method.
Ciudad Bazaul , Cristina, Salvadores Ferrando, María Paz   +1 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

СиÑÑема пожаÑной Ð¾Ñ ÑÐ°Ð½Ñ Ð¿ÑедпÑиÑÑиÑ

, 2017
Георгий Константинович Яшин
openalex   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

ÐÑенка ÑÑÑекÑивноÑÑи внедÑÐµÐ½Ð¸Ñ ÐÐШ на плаÑÑоÑме SAP-HR на пÑимеÑе гÑÑÐ¿Ð¿Ñ ÐºÐ¾Ð¼Ð¿Ð°Ð½Ð¸Ð¹ «ÐÐ-Рл

, 2016
Анастасия Олеговна Зубова
openalex   +1 more source