Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Exploring Implicit Emotional Associations With Death in Patients With Current Suicidal Ideation: Results From Novel Attitude Implicit Association Tests for Suicide. [PDF]
Suicide Life Threat BehavAschenbrenner LM +9 more
europepmc +1 more source
, 2016 The patients were treated with the method of psychoanalysis. They represented symptoms of the convertible fobicle neurosis. The author was an observer of the therapy, and at the same time, he was an object of the supervision of psychotherapist.
Мицев (Micev), Миодраг (Miodrag) +1 more
core
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Рнализ и оценка на операционните Ñ€Ð¸Ñ ÐºÐ¾Ð²Ðµ [PDF]
, 2020 Ð Ð ⁄ Ñ‚Ð ⁄ Ð ⁄ ГÐμруР⁄ Ð ⁄ Ð
openalex
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Patient and provider perspective with the use of a central intake system (CIS) for surgical waitlist management: a systematic review. [PDF]
BMJ OpenKennedy L, Asante BO, Clement F.
europepmc +1 more source
Molecular Oncology, EarlyView.This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima +6 more
wiley +1 more source
Diverse biofilm-forming <i>Sphingomonadaceae</i> represent twelve novel species isolated from glaciers on the Tibetan Plateau. [PDF]
Int J Syst Evol MicrobiolHan D, Xin YH, Liu Q.
europepmc +1 more source
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source