Results 241 to 250 of about 6,151,732 (298)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system. [PDF]
Proc Natl Acad Sci U S AMatsui S +12 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Description of 15 novel species within genus <i>Janthinobacterium</i> isolated from glaciers. [PDF]
Int J Syst Evol MicrobiolYang LL, Xin YH, Liu Q.
europepmc +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Association of genetic variation with age at diagnosis in type 1 diabetes. [PDF]
BMJ Open Diabetes Res CareVollenbrock CE +17 more
europepmc +1 more source