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Ð˜Ð¡Ð¥Ð ÐÐÐÐ¢Ð Ð˜ ÐˆÐÐ’ÐÐžÐ¢Ðž Ð—Ð”Ð ÐÐ’ÐˆÐ• – Ð¡ÐžÐ¡Ð¢ÐžÐˆÐ‘Ð, ÐŸÐžÐ›Ð˜Ð¢Ð˜ÐšÐ˜ Ð˜ ÐŸÐ Ð•Ð”Ð˜Ð—Ð’Ð˜Ð¦Ð˜ [PDF]

Food Allergy Based on Serum Specific IgE in Republic of Macedonia [PDF]

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source

ÐžÐ¡ÐžÐ‘Ð•ÐÐÐžÐ¡Ð¢Ð˜ Ð ÐÐ¡Ð§Ð•Ð¢Ð Ð¡Ð¢ÐžÐ˜ÐœÐžÐ¡Ð¢Ð˜ Ð—Ð•ÐœÐ•Ð›Ð¬ÐÐžÐ“Ðž Ð£Ð§ÐÐ¡Ð¢ÐšÐ Ð”Ð›Ð¯ Ð¡Ð¢Ð ÐžÐ˜Ð¢Ð•Ð›Ð¬Ð¡Ð¢Ð’Ð Ð˜ ÐžÐ‘Ð¡Ð›Ð£Ð–Ð˜Ð’ÐÐÐ˜Ð¯ Ð–Ð˜Ð›ÐžÐ“Ðž Ð”ÐžÐœÐ .

Ð•Ð¤Ð•ÐšÐ¢Ð˜ ÐÐ CYP3A4 Ð“Ð•ÐÐ•Ð¢Ð¡ÐšÐ˜ ÐŸÐžÐ›Ð˜ÐœÐžÐ Ð¤Ð˜Ð—ÐÐœ Ð’Ð Ð— ÐŸÐžÐ¡Ð¢ÐžÐŸÐ•Ð ÐÐ¢Ð˜Ð’ÐÐÐ¢Ð ÐŸÐžÐ¢Ð ÐžÐ¨Ð£Ð’ÐÐ§ÐšÐ ÐÐ Ð¤Ð•ÐÐ¢ÐÐÐ˜Ð› ÐŸÐ Ð˜ Ð¢Ð Ð•Ð¢ÐœÐÐ ÐÐ ÐŸÐžÐ¡Ð¢ÐžÐŸÐ•Ð ÐÐ¢Ð˜Ð’ÐÐÐ¢Ð Ð‘ÐžÐ›ÐšÐ [PDF]

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source

ÐŸÐžÐ”Ð“ÐžÐ¢ÐžÐ’ÐšÐ Ð¡Ð¢Ð£Ð”Ð•ÐÐ¢ÐžÐ’ Ðš ÐŸÐ ÐžÐ¤Ð•Ð¡Ð¡Ð˜ÐžÐÐÐ›Ð¬ÐÐžÐ™ Ð˜ÐÐÐžÐ’ÐÐ¦Ð˜ÐžÐÐÐžÐ™ Ð”Ð•Ð¯Ð¢Ð•Ð›Ð¬ÐÐžÐ¡Ð¢Ð˜ Ð’ Ð ÐÐœÐšÐÐ¥ Ð¡ÐŸÐ•Ð¦Ð˜ÐÐ›Ð¬ÐÐžÐ“Ðž Ð£Ð§Ð•Ð‘ÐÐžÐ“Ðž ÐšÐ£Ð Ð¡Ð

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source

, 2018
Non-communicable diseases, also known as modern-life diseases, are the leading cause of morbidity and mortality in the world and in the Republic of Macedonia. The complexity of their occurrence, often associated with multifactorial etiology and lifestyle
Ð¡Ð¿Ð°ÑÐ¾Ð²ÑÐºÐ¸ (Spasovski), ÐœÐ¾Ð¼Ðµ (Mome) +3 more
core +1 more source

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas +2 more
wiley +1 more source

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