Results 91 to 100 of about 5,658,907 (226)

Effects of Antiepileptic Drugs, Carbamazepine and Phenytoin, on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in Japanese Patients With Schizophrenia. [PDF]

Neuropsychopharmacol Rep
Ikawa K, Imura T, Nakamura S, Murata K, Morikawa N, Sakata M, Yasuzawa H, Horikawa N.   +7 more
europepmc   +1 more source

ÐŸÐµÑ€Ñ Ð¿ÐµÐºÑ‚Ð¸Ð²Ð¸ и проблеми на обучението по приложна етика в Ð£Ð½Ð¸Ð²ÐµÑ€Ñ Ð¸Ñ‚ÐµÑ‚Ð° за национално и Ñ Ð²ÐµÑ‚Ð¾Ð²Ð½Ð¾ Ñ Ñ‚Ð¾Ð¿Ð°Ð½Ñ Ñ‚Ð²Ð¾ [PDF]

, 2020
ВаРÐμÐ ⁄ Ñ‚Ð ̧Ð ⁄ а ДраР⁄ аРР̧ÐμРа
openalex  

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Definition and key concepts of high-performing health systems: a scoping review. [PDF]

BMJ Open
Cho V, Trowbridge J, Perreira T, Sodhi S, Karsan A, Hassan H, Perrier L, Prokopy M, Dale A, Brown A.   +9 more
europepmc   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Tracing Early Migratory Neurons in the Developing Nose Using Contactin-2 (Cntn2) CreERT2. [PDF]

Genesis
Amato E, Semon AM, Forni PE.
europepmc   +1 more source

Рнализ и оценка на операционните Ñ€Ð¸Ñ ÐºÐ¾Ð²Ðµ [PDF]

, 2020
Ð Ð ⁄ Ñ‚Ð ⁄ Ð ⁄ ГÐμруР⁄ Ð ⁄ Ð
openalex  

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A novel mouse model for studying complications related to type 2 diabetes using a medium-fat diet, fructose, and streptozotocin. [PDF]

Sci Rep
Mazzocco YL, Bergero G, Del Rosso S, Cejas Gallardo ZM, Canalis AM, Baigorri RE, Mezzano L, Mladin JJ, Díaz-Gerevini GT, Martínez Benavidez C, Cano RC, Aoki MP.   +11 more
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source