Results 101 to 110 of about 5,658,907 (226)

Comorbidity clusters and their relationship with severity and outcomes of index diseases, in a large multicentre systemic lupus erythematosus cohort. [PDF]

Lupus Sci Med
Rua-Figueroa I, Pérez-Veiga N, Rodríguez-Almaraz E, Galindo-Izquierdo M, Erausquin C, Fernandez-Nebro A, Uriarte Itzazelaia E, Serrano-Benavente B, Calvo Alén J, Manrique-Arija S, Senabre JM, Bernal JA, Narvaez J, Tomero E, Aurrecoechea E, Ibáñez-Barceló M, Segarra VT, Sangüesa C, Freire-González M, García-Villanueva MJ, Martínez Taboada V, Arevalo M, Morales CM, Iñiguez C, Perez A, Salgado E, Carrión-Barberà I, Andreu JL, Cobo T, Horcada L, Bonilla G, Lozano-Rivas N, Exposito L, Montilla C, Toyos FJ, Ibarguengoitia-Barrena O, Valls Pascual E, Nóvoa Medina J, Menor-Almagro R, Roman Ivorra JA, Muñoz Jiménez A, Nolla JM, Pego-Reigosa JM.   +42 more
europepmc   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Expert consensus on solutions to improve implementation of NICE type 2 diabetes guideline (NG28) by health systems in England: a Delphi panel by the INNOVATE-28 Working Group. [PDF]

BMJ Open
Tahir W, Beba H, Fortes-Mayer G, Kar P, Khan N, Milne N, Moore J, Saha S, Atkin M.   +8 more
europepmc   +1 more source

ХимичеÑкие компоненты Ñурепки обыкновенной

, 2012
М. М. Маренич, S. Rakhmadiyeva, Ye. Aibuldinov   +2 more
openalex  

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats. [PDF]

Sci Rep
Alshahawy RZ, Safwat SM, El-Kholy SS, El-Basiony SF, El-Desouky S, Helmi SM.   +5 more
europepmc   +1 more source

Ðлергии на храна врз оÑнова на ÑерумÑки Ñпецифичен ИгЕ во Република Македонија

, 2015
Slavica Hristomanova, Дејан Трајков, Александар Петличковски, Оливија Ефинска-Младеновска, Мирко Спироски   +4 more
openalex  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Accurate Prediction of HOMO-LUMO Gap Using DFT Functional and Application to Next-Generation Organic Telluro[n]Helicenes Materials. [PDF]

J Comput Chem
Kumar R, Kar R, Maity DK.
europepmc   +1 more source

Улогата на медицинÑката ÑеÑтра во MакедонÑката банка за хумана ДÐК

, 2015
Elena Cvetkovska, Мирко Спироски   +1 more
openalex