Results 191 to 200 of about 6,329,421 (270)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

ÐÑо меÑÐµÐ¶Ñ RFWKIDEA16-8, RFWKIDEA16-4, RFWKIDEA16-2 Ñа RFWKIDEA16-1, ÑÑвоÑÐµÐ½Ñ Ð½Ð° оÑÐ½Ð¾Ð²Ñ Ð¼ÐµÑÐµÐ¶Ñ IDEA16-8

, 2014
Туйчиев, Гулом Нумонович; Национальный университет Узбекистана им. Мирзо Улугбека
openalex   +1 more source

IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism. [PDF]

Diabetes
Lu X, Bai N, Lyu J, Sun J, Su Y, Ye Y, Hu T, Liu T, Li W, Li X, Ma X, Yang Y, Bao Y.   +12 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

ÐизнаÑÐµÐ½Ð½Ñ Ð¾ÑганÑÐ·Ð¾Ð²Ð°Ð½Ð¾Ñ Ð·Ð»Ð¾ÑинноÑÑÑ Ñ Ð±Ð¾ÑоÑÑба з Ð½ÐµÑ Ð·Ð° кÑимÑналÑним законодавÑÑвом РеÑпÑблÑки ÐолÑÑа

, 2016
Аneta; Університет Марії Кюрі-Склодовської Michalska-Warias
openalex   +1 more source

РеÑÑÑÑнÑй поÑенÑиал ÑоÑгового пÑедпÑиÑÑиÑ: оÑенка и пÑÑи повÑÑÐµÐ½Ð¸Ñ ÑÑÑекÑивноÑÑи иÑполÑзованиÑ

, 2016
Афонская, Дарья
openalex   +1 more source

Association Between Vitamin D Deficiency and Cardiovascular Disease Risk Factors in the MENA Population: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Bucheeri S, Mubarak A, Aldoseri J, Redha A, Kumar N, Mohamed S.   +5 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

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, 2015

openalex   +1 more source

The Impact of Serum 25-Hydroxyvitamin D on Bone Mineral Density at Different Skeletal Sites: A Multivariate Analysis Based on a UK Cohort Study. [PDF]

Food Sci Nutr
Zeng H, Tong X, Cui S, Shen C, Li J, Lin Q, Huang Y, Yao XI.   +7 more
europepmc   +1 more source