Results 111 to 120 of about 9,179,318 (244)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2017 It has been examined the possibility of thyroid tissue as to how as a same antigen influence on blast - transformation, eventually on previously sensitised lymphocytes at thyrotoxicosis patients.The lymphocytes have been separated (taken) from the vein ...
Малинова (Malinova), Љубинка (Ljubinka) +1 more
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Perturbations in $$\textbf{O}(D,D)$$ O ( D , D ) string cosmology from double field theory
European Physical Journal C: Particles and FieldsThe low-energy limit of string theory contains additional gravitational degrees of freedom, a skew-symmetric tensor B-field and a scalar dilaton, that are not present in general relativity.
Stephen Angus, Shinji Mukohyama
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
PCI Mac го подигнува нивото на преформанÑи
, 2016 изваР...
информатика, МЕДИС -
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Содржина, декември, 1996, волумен 3, број 23
, 2016 ИзваР...
информатика, МЕДИС -
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Kлинички тек и иÑход кај пациенти Ñо рано дијагноÑтицирани конгенитални малформации на бубрезите и уринарниот тракт [PDF]
, 2018 Congenital anomalies of the kidney and urinary tract- CAKUT are common childhood pathology accounting for 20-30% of all perinatally detected congenital anomalies. The importance of CAKUT is the risk they represent to kidney function deterioration and end-
ПапазовÑка-ЧерепналковÑки (Papazovska-Cherepnalkovski), Ðнет (Anet) +6 more
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