Results 131 to 140 of about 6,425,805 (257)
ÐšÐ»Ð¸Ñ€ÐµÐ½Ñ Ð½Ð° I-131 и Ts-99 во тиреоидеа кај Ñтаорец
, 2017 Thyroid clearance of J-131 and Tc-99m after simultaneous subcutaneous injection in rats were estimated in the early phase. Arterial blood samples were drawn with a polyethene catheter inserted in the iliac artery in intervals of two minutes.
ГеоргиевÑки (Georgievski), Славко (Slavko) +1 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2017 The aim of our examination was to establish the number of suicides, oldness, sex, professions, calendar and meteorological time, place, manner and means of execution. Our basic duty was to analyse this phenomenon, which number rise slowly, from the year (
ИвановÑки (Ivanovski), Мартин (Martin) +2 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Три Ñлучаи на Syndroma Willi Prader Labhardt во доенечка возраÑÑ‚
, 2017 Authors presented three cases of Willi Prader Labhardt Syndroma whose cardinal symptoms are: psychomotor retardation, proportional obesity, hypogenitalism, a small bifrontal circumference, and carp-like mouth.During the pregnancy, children's mothers felt
Гордова-МуратовÑка (Gordova-Muratovska), ÐлекÑандра (Aleksandra) +2 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
, 2018 Non-communicable diseases, also known as modern-life diseases, are the leading cause of morbidity and mortality in the world and in the Republic of Macedonia. The complexity of their occurrence, often associated with multifactorial etiology and lifestyle
Пецев (Pecev), Петар (Petar) +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2016 The pertechnetate concentrating mechanism in thyroid gland, salivary glands and stomach was studied in rats by determination tissue: plasma radioactivity ratio.
Серафимов (Serafimov), Ðикола (Nikola) +2 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source