Results 71 to 80 of about 663 (164)

DKK3 Initially Preserves Acinar Integrity Through MEK‐Fos Signaling, but Later Switches to an Oncogenic Role in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
In pancreatic cancer, the protein DKK3 is found to play a complex role: it initially slows early tumor growth but later promotes tumor aggressiveness. DKK3 expression evolves during progression and drives cancer severity by orchestrating cellular and molecular signaling pathways.
Dharini Srinivasan   +20 more
wiley   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

open access: yesAdvanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye   +7 more
wiley   +1 more source

Classical Path Methods in Line Broadening. I. The Classical Path Approximation. [PDF]

open access: yesJ Res Natl Bur Stand A Phys Chem, 1969
Smith EW, Vidal CR, Cooper J.
europepmc   +1 more source

Deconstruction of the Anisotropic Magnetic Interactions from Spin‐Entangled Optical Excitations in van der Waals Antiferromagnets

open access: yesAdvanced Science, EarlyView.
A self‐consistent ab initio many‐body perturbation theory combined with locally exact dynamical mean field theory is employed to compute the sub‐bandgap electronic transitions in van der Waals antiferromagnets. The rich interplay between the magnetic ordering and spin‐entangled optical transitions, manifested as photoluminescence and absorption ...
Dipankar Jana   +7 more
wiley   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

open access: yesAdvanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan   +20 more
wiley   +1 more source

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