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Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source

ÐŸÐ Ð˜Ð¡Ð¢ÐÐŸ Ð”Ðž Ð‘Ð•Ð—Ð‘Ð•Ð”ÐÐ Ð’ÐžÐ”Ð Ð—Ð ÐŸÐ˜Ð•ÐŠÐ• Ð’Ðž Ð¡Ð•Ð’Ð•Ð ÐžÐ˜Ð¡Ð¢ÐžÐ§ÐÐ˜ÐžÐ¢ Ð Ð•Ð“Ð˜ÐžÐ ÐÐ Ð Ð•ÐŸÐ£Ð‘Ð›Ð˜ÐšÐ ÐœÐÐšÐ•Ð”ÐžÐÐ˜ÐˆÐ- Ð Ð•Ð¢Ð ÐžÐ¡ÐŸÐ•ÐšÐ¢Ð˜Ð’ÐÐ ÐÐÐÐ›Ð˜Ð—Ð [PDF]

Structure of Patients Treated in Intensive Coronary Care Unit on Department for Internal Medicine â€“ PHO General Hospital Kumanovo â€“ in the Period from 2009-2013 Year [PDF]

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source

, 2018
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Ð¢Ð¾Ð·Ð¸Ñ˜Ð° (Tozija), Ð¤Ð¸Ð¼ÐºÐ° (Fimka)
core +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source

, 2017
The study aims to compare the conventional open technique for treating inguinal hernia versus laparoscopic assisted technique of percutaneous closure of the internal inguinal ring in female children with clinically diagnosed indirect inguinal hernia ...
Ð Ð¸ÑÑ‚ÐµÑÐºÐ¸ (Risteski), Ð¢Ð¾Ð½Ð¸ (Toni) ÐœÐ¸Ñ€Ñ‡Ðµ (Mirce) +4 more
core +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source

Letter: Changes in Blood Lactates during Ergometric Testing on Professional Football Players during One Half Season Competitions (Maced Med Electr J. 2015 Oct 02; 2015;50012. http://dx.doi.org/10.3889/mmej.2015.50012) [PDF]

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