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Ð¢Ñ€Ð¸ ÑÐ»ÑƒÑ‡Ð°Ð¸ Ð½Ð° Syndroma Willi Prader Labhardt Ð²Ð¾ Ð´Ð¾ÐµÐ½ÐµÑ‡ÐºÐ° Ð²Ð¾Ð·Ñ€Ð°ÑÑ‚ [PDF]

, 2017
Authors presented three cases of Willi Prader Labhardt Syndroma whose cardinal symptoms are: psychomotor retardation, proportional obesity, hypogenitalism, a small bifrontal circumference, and carp-like mouth.During the pregnancy, children's mothers felt
Ð¡Ð¿Ð¸Ñ€Ð¾Ð²ÑÐºÐ¸, Ð—Ð¾Ñ€Ð°Ð½ +2 more
core +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky +2 more
wiley +1 more source

, 2017
Laboratory acquired infections (LAI) are all infections obtained during laboratory work, divided into several types, according to the manner of occurrence.
Kakaraskoska Boceska (ÐšÐ°ÐºÐ°Ñ€Ð°ÑÐºÐ¾ÑÐºÐ° Ð‘Ð¾Ñ†ÐµÑÐºÐ°), Biljana (Ð‘Ð¸Ñ™Ð°Ð½Ð°)
core +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt +4 more
wiley +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source

, 2018
Non-communicable diseases, also known as modern-life diseases, are the leading cause of morbidity and mortality in the world and in the Republic of Macedonia. The complexity of their occurrence, often associated with multifactorial etiology and lifestyle
Ð¡Ð¿Ð°ÑÐ¾Ð²ÑÐºÐ¸ (Spasovski), ÐœÐ¾Ð¼Ðµ (Mome) +3 more
core +1 more source

Neurolupus [PDF]

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source

, 2017
Epidemiological data indicates that thyroid carcinoma (TC) is the most frequent endocrinological tumors, participating with around 1% from all malignomas.
Ð¢Ñ€Ð¸Ð¿ÑƒÐ½Ð¾ÑÐºÐ¸ (Tripunoski), Ð¢Ð¾Ð½Ð¸ (Toni) +3 more
core +1 more source

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