Results 251 to 260 of about 5,871,734 (286)

Exploring novel thiazolo[5,4-f]quinoline-based scaffolds as promising antimicrobial agents through synthesis and molecular insights. [PDF]

Sci Rep
Soliman NN, Fadda AA, Gaffer HE, Bayoumy NM.   +3 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Genome sequencing and physiological characterization of three Neoarthrinium moseri strains. [PDF]

BMC Microbiol
Hochenegger NJ, Vignolle GA, Schmal M, Mach RL, Mach-Aigner AR, Rahimi MJ, Chan CM, Cai FM, Druzhinina IS, Zimmermann C.   +9 more
europepmc   +1 more source

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source

Erratum to Mlakar-Mastnak D, Blaž Kovač M, Terčelj M, Uhan S, Majdič N, Rotovnik Kozjek N. Effectiveness of nutritional intervention led by clinical dietitian in patients at risk of malnutrition at the primary healthcare level in Slovenia - evaluation study. Zdr Varst. 2024;63(2):81-88. doi: 10.2478/sjph-2024-0012. [PDF]

Zdr Varst
europepmc   +1 more source

Non-pharmacological interventions for delirium in critically ill children: a scoping review. [PDF]

BMJ Open
Zilezinski M, Denninger NE, Tannen A, Kottner J.   +3 more
europepmc   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Relationship between left ventricular wall stress and cardiac remodelling post-TAVR and MitraClip. [PDF]

Open Heart
Papapostolou S, Kearns JS, Costello B, O'Brien J, Gutman S, Nanayakkara S, Kaye DM, Walton A, Hare J, Stub D, Taylor A.   +10 more
europepmc   +1 more source

Osmotic pressure‐induced calcium response states

FEBS Open Bio, EarlyView.
Acute hypotonic stress triggers distinct calcium response patterns in HEK293T cells. These signals originate from the endoplasmic reticulum via RyR2 and propagate to neighboring cells through gap junctions. This result highlights a novel calcium‐dependent mechanism underlying the intracellular and intercellular response to osmotic pressure.
Zidan Gao, Keiji Naruse, Masatoshi Morimatsu   +2 more
wiley   +1 more source

Cerebral glucose delivery, transport and metabolism: Theory and modeling using four, three, and two tissue compartments. [PDF]

J Cereb Blood Flow Metab
Seidemo A, Knutsson L, Yadav NN, Sundgren PC, Wirestam R, van Zijl PC.   +5 more
europepmc   +1 more source