Results 221 to 230 of about 6,308,757 (253)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Author Correction: Emergent patterns of patchiness differ between physical and planktonic properties in the ocean. [PDF]

Nat Commun
Gray PC, Boss E, Bourdin G, Mission Microbiomes AtlantECO, Tara Pacific Consortium, Mission Microbiomes CEODOS Chile, Lehahn Y.   +6 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Fear of Cancer Recurrence Before Treatment in Patients Newly Diagnosed With Breast Cancer: Cross-Sectional Study.

JMIR Cancer
Ding Y, Zhang H, Zhong Q, Zhang L, Qin H.   +4 more
europepmc   +1 more source

Quantitative β-Cell Mass Imaging Redefines Disease Staging and Glycemic Control in Type 1 Diabetes. [PDF]

Diabetes
Sakaki K, Murakami T, Yoshida H, Otani D, Miyake KK, Shimizu Y, Fujimoto H, Yabe D, Nakamoto Y, Inagaki N.   +9 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Association of Circulating Vitamin D in Midlife With Increased Tau-PET Burden in Dementia-Free Adults. [PDF]

Neurol Open Access
Mulligan MD, Scott MR, Yang Q, Wang R, Ghosh S, Johnson KA, Beiser AS, Seshadri S, McGrath ER.   +8 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Hybrid intelligent RSM-ANN modeling and optimization of precision turning of CK45 steel for calibration devices. [PDF]

Sci Rep
Farouk WM, Ahmed AG, Gamil M, Nasser FT, Abu-Okail M, Elamy MI.   +5 more
europepmc   +1 more source