ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Little strings on D n orbifolds
We explore two classes of 6d N = 1 0 $$ \mathcal{N}=\left(1,0\right) $$ little string theories obtained from type IIA/IIB NS5-branes probing D n singularities.
Joonho Kim, Kimyeong Lee
doaj +1 more source
Когнитивниот дефицит кај возраÑни пациенти по анеÑтезија во не–кардијалната хирургија [PDF]
Studies of the early 21st century indicate that the decline in cognitive functionis as a complication of anesthesia and operative intervention. Whether there would be changes and the amount of changes in mental status will cause a type of anesthesia is a
Трајкова, Радмила +2 more
core +1 more source
Животниот Ñтил и контрола на хроничните незаразни болеÑти [PDF]
Non-communicable diseases, also known as modern-life diseases, are the leading cause of morbidity and mortality in the world and in the Republic of Macedonia. The complexity of their occurrence, often associated with multifactorial etiology and lifestyle
СпаÑовÑки (Spasovski), Моме (Mome) +3 more
core +1 more source
The Role of Exhaled Nitric Oxide in Childhood Asthma Management [PDF]
ÐÑтмата претÑтавува хронична инфламаторна болеÑÑ‚ на дишните патишта која Ñе карактеризира Ñо реверзибилна бронхообÑтрукција и појава на Ñимп
Jovkovska-Kaeva, Biserka +1 more
core +2 more sources
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait +23 more
wiley +1 more source
Degree sequence for k-arc strongly connected multiple digraphs
Let D be a digraph on { v 1 , … , v n } $\{v_{1},\ldots, v_{n}\}$ . Then the sequence { ( d + ( v 1 ) , d − ( v 1 ) ) , … , ( d + ( v n ) , d − ( v n ) ) } $\{ (d^{+}(v_{1}), d^{-}(v_{1})), \ldots, (d^{+}(v_{n}), d^{-}(v_{n}))\}$ is called the degree ...
Yanmei Hong, Qinghai Liu
doaj +1 more source
БезбедноÑта во Ñообраќајот на патиштата – предизвици за јавноздравÑтвен одговор [PDF]
Road traffic safety is a high-priority public health problem. In the world annually, around 1.25 million people die on roads as a result of road traffic accidents (2.1% of global mortality), and 20-50 million people are injured and remain with life-long ...
Тозија (Tozija), Фимка (Fimka)
core +1 more source
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman +8 more
wiley +1 more source
ÐÐТИМИКРОБÐРРЕЗИСТЕÐЦИЈР(ÐМР) ВО ЕВРОПРИ БÐЛКÐÐСКИОТ РЕГИОР– ПРЕГЛЕД ÐРСЕГÐШÐÐТРСОСТОЈБР[PDF]
Ðнтимикробната резиÑтенција (ÐМР) претÑтавува глобален проблем, чијшто размер е оÑобено загрижувачки во оние земји каде што не поÑтојат довол
ХриÑтова, КриÑтина +6 more
core +1 more source

