Results 101 to 110 of about 6,425,400 (257)
, 2017 It was interesting to examine how the sport impresses at functional (motorial) characteristics of students.About that intention there were examined, 2306 students of whom 1232 girls and 1076 boys, with the age of 14-18 years.There were examined the ...
СтолевÑки (Stolevski), Владо (Vlado) +1 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2018 The verification of the qualitative method with test devices for detection of eight drugs of abuse in urine (amphetamines, methamphetamine, barbiturates, benzoylecgonine, marijuana, 3,4-methylendioxy-methamphetamine, methadone, and opiates) was ...
ТошеÑка-ТрајковÑка (Tosheska-Trajkovska), Катерина (Katerina) +4 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2016 In atempt to get elementary insight of interpheron action on leukocyte fagocytable capacity, in vitro were tested fagocytes from the patients with various diseases.
Младеновиќ (Mladenovikj), ДрагоÑлав (Dragoslav) +1 more
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Aẓar deg tmaziγt d allal n usileγ n tayunin timaynutin
Langues & CulturesDeg tmaziɣt, asileɣ n umawal ibedd ɣef sin n yikalayen igejdanen : asuddem d usuddes. Maca, mi ara nmuqqel ɣer wuṭṭun n tayunin i d-yettalɣen, ad d-negzu dakken yella lexṣaṣ deg tayunin n umawal imi addayen n usuddem drus i yellan, d ayen i ɣ-yettawin ...
Mahdi YAHIAOUI
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2017 The levels of estradiol, progesterone and gonadotropins were determined by radioimmunoassay in 8 healthy women, aging 18-22 years, with histories of regular menstruation.
ДеловÑка (Delovska), ВеÑна (Vesna) +1 more
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