Results 131 to 140 of about 20,294,267 (243)
PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu +13 morewiley +1 more sourceAn inflammatory cytokine signature predicts COVID-19 severity and survival
Nature Medicine, 2020 D. D. Del Valle, S. Kim-Schulze, Hsin-Hui Huang, N. Beckmann, Sharon Nirenberg, Bo Wang, Yonit Lavin, Talia H. Swartz, D. Madduri, A. Stock, T. Marron, Hui Xie, Manishkumar Patel, K. Tuballes, O. Van Oekelen, Adeeb H. Rahman, P. Kovatch, J. Aberg, E. Schadt, S. Jagannath, M. Mazumdar, A. Charney, A. Firpo-Betancourt, D. R. Mendu, J. Jhang, D. Reich, K. Sigel, C. Cordon-Cardo, M. Feldmann, S. Parekh, M. Merad, S. Gnjatic +31 moresemanticscholar +1 more sourceInhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge +18 morewiley +1 more sourceA synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote +8 morewiley +1 more sourcePlanck 2015 results: XXIII. The thermal Sunyaev-Zeldovich effect-cosmic infrared background correlation
, 2016 P. Ade, N. Aghanim, M. Arnaud, J. Aumont, C. Baccigalupi, A. Banday, A. Banday, R. B. Barreiro, J. G. Bartlett, J. G. Bartlett, N. Bartolo, N. Bartolo, E. Battaner, K. Benabed, A. Benoit-Lévy, A. Benoit-Lévy, J. Bernard, J. Bernard, M. Bersanelli, M. Bersanelli, P. Bielewicz, P. Bielewicz, J. Bock, A. Bonaldi, L. Bonavera, J. R. Bond, J. Borrill, J. Borrill, F. Bouchet, C. Burigana, C. Burigana, R. C. Butler, E. Calabrese, A. Catalano, A. Chamballu, A. Chamballu, A. Chamballu, H. Chiang, H. Chiang, P. Christensen, E. Churazov, E. Churazov, D. Clements, L. Colombo, L. Colombo, C. Combet, B. Comis, F. Couchot, A. Coulais, B. Crill, A. Curto, A. Curto, F. Cuttaia, L. Danese, R. Davies, R. J. Davis, P. Bernardis, A. Rosa, G. Zotti, G. Zotti, J. Delabrouille, C. Dickinson, J. M. Diego, H. Dole, H. Dole, S. Donzelli, O. Doré, M. Douspis, A. Ducout, A. Ducout, X. Dupac, G. Efstathiou, F. Elsner, F. Elsner, T. Ensslin, H. Eriksen, F. Finelli, I. Flores-Cacho, I. Flores-Cacho, O. Forni, O. Forni, M. Frailis, A. Fraisse, E. Franceschi, S. Galeotta, S. Galli, K. Ganga, R. Génova-Santos, R. Génova-Santos, M. Giard, M. Giard, Y. Giraud-Héraud, E. Gjerløw, J. González-Nuevo, J. González-Nuevo, K. Górski, K. Górski, A. Gregorio, A. Gregorio, A. Gruppuso, J. Gudmundsson, F. Hansen, D. Harrison, G. Helou, C. Hernández-Monteagudo, D. Herranz, S. Hildebrandt, E. Hivon, M. Hobson, A. Hornstrup, W. Hovest, K. Huffenberger, G. Hurier, A. Jaffe, T. Jaffe, T. Jaffe, W. Jones, E. Keihänen, R. Keskitalo, T. Kisner, R. Kneissl, R. Kneissl, J. Knoche, M. Kunz, M. Kunz, M. Kunz, H. Kurki-Suonio, G. Lagache, G. Lagache, J. Lamarre, M. Langer, A. Lasenby, M. Lattanzi, C. Lawrence, R. Leonardi, F. Levrier, P. Lilje, M. Linden-Vørnle, M. López-Caniego, M. López-Caniego, P. Lubin, J. Macías-Pérez, B. Maffei, G. Maggio, D. Maino, D. Maino, D. Mak, N. Mandolesi, N. Mandolesi, A. Mangilli, M. Maris, P. Martin, E. Martínez-González, S. Masi, S. Matarrese, S. Matarrese, A. Melchiorri, A. Mennella, A. Mennella, M. Migliaccio, S. Mitra, S. Mitra, M. Miville-Deschênes, M. Miville-Deschênes, A. Moneti, L. Montier, L. Montier, G. Morgante, D. Mortlock, D. Munshi, J. A. Murphy, F. Nati, P. Natoli, P. Natoli, P. Natoli, F. Noviello, D. Novikov, I. Novikov, I. Novikov, C. A. Oxborrow, F. Paci, L. Pagano, F. Pajot, D. Paoletti, B. Partridge, F. Pasian, T. Pearson, O. Perdereau, L. Perotto, V. Pettorino, F. Piacentini, M. Piat, E. Pierpaoli, S. Plaszczynski, E. Pointecouteau, E. Pointecouteau, G. Polenta, G. Polenta, N. Ponthieu, N. Ponthieu, G. Pratt, S. Prunet, J. Puget, J. Rachen, J. Rachen, M. Reinecke, M. Remazeilles, M. Remazeilles, M. Remazeilles, C. Renault, A. Renzi, I. Ristorcelli, I. Ristorcelli, G. Rocha, C. Rosset, M. Rossetti, M. Rossetti, G. Roudier, G. Roudier, G. Roudier, J. Rubiño-Martín, J. Rubiño-Martín, B. Rusholme, M. Sandri, D. Santos, M. Savelainen, G. Savini, D. Scott, L. Spencer, V. Stolyarov, V. Stolyarov, V. Stolyarov, R. Stompor, R. Sunyaev, R. Sunyaev, D. Sutton, A.-S. Suur-Uski, J. Sygnet, J. Tauber, L. Terenzi, L. Toffolatti, L. Toffolatti, L. Toffolatti, M. Tomasi, M. Tomasi, M. Tristram, M. Tucci, G. Umana, L. Valenziano, J. Valiviita, B. Tent, P. Vielva, F. Villa, L. Wade, B. Wandelt, B. Wandelt, I. Wehus, N. Welikala, D. Yvon, A. Zacchei, A. Zonca +260 moresemanticscholar +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourcePatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourcePredictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman +17 morewiley +1 more source
