Results 151 to 160 of about 20,294,267 (243)
CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane +12 morewiley +1 more sourceReduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh +8 morewiley +1 more sourceEffects of Vitamin D and Calcium Supplementation on Falls: A Randomized Controlled Trial
Journal of Bone and Mineral Research, 2003 H. Bischoff, H. B. Stähelin, W. Dick, Regula Akos, Margrith E Knecht, Christian Salis, M. Nebiker, R. Theiler, M. Pfeifer, B. Begerow, R. Lew, M. Conzelmann +11 moresemanticscholar +1 more sourceLiquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen +2 morewiley +1 more sourceAPS : Review of Particle Physics, 2018
, 2018 M. Tanabashi, Peter J. Richardson, A. Bettini, A. Vogt, L. Garren, A. Schwartz, K. Terashi, M. Karliner, R. Chivukula, T. Sjöstrand, J. Beringer, S. Bethke, G. Gerbier, P. Nason, H. Dreiner, Y. Kwon, J. Beatty, E. Pianori, M. Silari, J. Peacock, A. Cerri, A. D. Gouvea, R. Zhu, C. Bauer, T. Mannel, T. Liss, M. Pennington, D. Tovey, Fabio Sauli, K. Johnson, Stephene R. Sharpe, C. Hanhart, T. Sumiyoshi, J. Anderson, H. Baer, J. Matthews, H. Gallagher, D. Chakraborty, T. DeGrand, L. Wiencke, H. Haber, A. Hocker, F. Moortgat, M. Antonelli, A. Quadt, J. Tanaka, P. A. Zyla, G. Venanzoni, Y. Hayato, G. D'Ambrosio, C. Sachrajda, U. Thoma, G. Rybka, D. Groom, Matthias Neubert, G. P. Salam, H. Bichsel, E. Weinberg, K. Hikasa, A. Pomarol, P. Skands, S. Navas, D. Wands, A. Freitas, G. Aielli, Z. Ligeti, A. Ringwald, P. Nevski, T. Shutt, M. Titov, T. Hyodo, D. Weinberg, S. Stone, K. Agashe, A. Masoni, O. Buchmuller, D. Scott, S. L. Zhu, L. Fuller, S. Griso, Alan D. Martin, K. S. Lugovsky, H. Murayama, K. Hagiwara, R. Ryutin, M. Drees, C. Grab, S. Banerjee, B. Fields, M. Goodman, M. A. Bychkov, B. Heltsley, D. Dwyer, T. Basaglia, Chunqing Lin, D. Florian, G. Raffelt, H. Spieler, F. Zimmermann, J. Rademacker, S. Rolli, C. Grojean, Burkert, C. Amsler, J. Lesgourgues, T. Gutsche, J. Erler, K. Mönig, G. Valencia, Y. Gershtein, J. Terning, J. Smith, J. Womersley, A. Lusiani, J. Ellis, Y. Sakai, A. Piepke, E. Klempt, A. Stahl, K. D. Irwin, A. Gritsan, P. Eerola, V. Petrov, G. Smoot, S. Sarkar, G. Zeller, W. J. Marciano, K. Olive, C. Patrignani, R. L. Workman, F. Maltoni, G. Dissertori, Y. Sumino, C. Spiering, Yu. V. Kuyanov, U. Meissner, M. Carena, B. Krusche, R. Mitchell, T. Gershon, F. Krauss, M. Narain, N. Varelas, W. Walkowiak, Ezhela, K. Hayes, A. Ceccucci, Stefan Roesler, F. Takahashi, J. Hisano, P. Vogel, M. Wascko, L. Verde, S. Petcov, M. Syphers, V. Belousov, O. Lahav, O. Zenin, C. Woody, A. Liddle, M. D’Onofrio, M. Kado, O. Dahl, S. Klein, M. Moskovic, D. Asner, A. Gurtu, D. Ward, M. C. Chen, S. Heinemeyer, R. Kowalewski, A. Godizov, D. Milstead, M. Vincter, S. Eidelman, R. Firestone, L. Rosenberg, M. Grünewald, K. Black, N. P. Tkachenko, B. Dobrescu, T. Gherghetta, W. Yao, S. Willocq, R. Barnett, A. Holtkamp, L. Littenberg, M. Kreps, R. Thorne, O. Schneider, P. Molaro, W. Fetscher, J. Holder, N. Tornqvist, E. Blucher, P. Schaffner, U. Katz, A. Romaniouk, P. D. Jong, B. Foster, Sharma, S. Hashimoto, K. Scholberg, R. D. Water, T. Skwarnicki, C. Walter, J. Parsons, G. Weiglein, R. Cahn, C. Wohl, J. Rosner, V. S. Lugovsky, B. Ratcliff, Martin White, Y. Nir, H. Gerber, S. Wakely, C. Lippmann, J. Laiho, O. Biebel, J. Hernández-Rey, T. Damour, G. Cowan, Y. Makida, L. Tiator, M. Doser, S. Spanier, S. Lugovsky, A. Hebecker, Kei Nakamura, A. Manohar +230 moresemanticscholar +1 more sourceIntein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar +9 morewiley +1 more source