Results 171 to 180 of about 20,294,267 (243)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees +6 morewiley +1 more sourceDual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix +13 morewiley +1 more sourceEffect of Vitamin D Supplementation on Cardiometabolic Outcomes in Older Australian Adults-Results from the Randomized Controlled D-Health Trial. [PDF]
NutrientsDuarte Romero BL, Armstrong BK, Baxter C, English DR, Ebeling PR, Hartel G, Kimlin MG, Na R, McLeod DSA, Pham H, Ross T, van der Pols JC, Venn AJ, Webb PM, Whiteman DC, Neale RE, Waterhouse M. +16 moreeuropepmc +1 more sourceRare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Nature Genetics, 2017 R. Sims, S. J. van der Lee, A. Naj, C. Bellenguez, N. Badarinarayan, J. Jakobsdóttir, B. Kunkle, A. Boland, R. Raybould, J. Bis, E. Martin, B. Grenier‐Boley, S. Heilmann-Heimbach, V. Chouraki, A. Kuzma, K. Sleegers, M. Vronskaya, A. Ruiz, R. Graham, R. Olaso, P. Hoffmann, Megan L. Grove, B. Vardarajan, M. Hiltunen, M. Nöthen, Charles C. White, K. Hamilton-Nelson, J. Epelbaum, W. Maier, S. Choi, G. Beecham, C. Dulary, S. Herms, A. Smith, Cory C. Funk, C. Derbois, A. Forstner, S. Ahmad, Hongdong Li, D. Bacq, D. Harold, C. Satizabal, O. Valladares, A. Squassina, Rhodri Thomas, J. Brody, L. Qu, P. Sánchez-Juan, T. Morgan, F. Wolters, Yi Zhao, Florentino Sanchez Garcia, N. Denning, M. Fornage, J. Malamon, M. Naranjo, E. Majounie, T. Mosley, B. Dombroski, D. Wallon, Michelle K. Lupton, J. Dupuis, P. Whitehead, L. Fratiglioni, C. Medway, X. Jian, Shubhabrata Mukherjee, L. Keller, K. Brown, Honghuang Lin, L. Cantwell, F. Panza, B. McGuinness, S. Moreno-Grau, J. Burgess, V. Solfrizzi, P. Proitsi, H. Adams, M. Allen, D. Seripa, P. Pastor, L. Cupples, N. Price, D. Hannequin, A. Frank‐García, D. Levy, Paramita Chakrabarty, P. Caffarra, I. Giegling, A. Beiser, V. Giedraitis, H. Hampel, M. Garcia, Xue Wang, L. Lannfelt, P. Mecocci, G. Eiriksdottir, P. Crane, F. Pasquier, V. Boccardi, I. Henández, R. Barber, M. Scherer, L. Tárraga, P. Adams, M. Leber, Yuning Chen, M. Albert, S. Riedel-Heller, V. Emilsson, D. Beekly, A. Braae, R. Schmidt, D. Blacker, C. Masullo, H. Schmidt, R. Doody, G. Spalletta, W. Longstreth, T. Fairchild, P. Bossù, O. Lopez, M. Frosch, E. Sacchinelli, B. Ghetti, Qiong Yang, R. Huebinger, F. Jessen, Shuo Li, M. Kamboh, J. Morris, O. Sotolongo-Grau, M. Katz, C. Corcoran, M. Dunstan, A. Braddel, C. Thomas, A. Meggy, R. Marshall, A. Gerrish, J. Chapman, M. Aguilar, S. Taylor, M. Hill, M. Fairén, A. Hodges, B. Vellas, H. Soininen, I. Kloszewska, M. Daniilidou, J. Uphill, Y. Patel, J. T. Hughes, J. Lord, J. Turton, A. Hartmann, R. Cecchetti, C. Fenoglio, M. Serpente, M. Arcaro, C. Caltagirone, M. D. Orfei, A. Ciaramella, S. Pichler, M. Mayhaus, W. Gu, A. Lleó, J. Fortea, R. Blesa, I. Barber, K. Brookes, C. Cupidi, R. Maletta, D. Carrell, S. Sorbi, S. Moebus, M. Urbano, A. Pilotto, J. Kornhuber, P. Bosco, S. Todd, D. Craig, J. Johnston, M. Gill, B. Lawlor, A. Lynch, Nick C Fox, J. Hardy, R. Albin, L. Apostolova, S. Arnold, S. Asthana, C. Atwood, C. Baldwin, L. Barnes, S. Barral, T. Beach, J. Becker, E. Bigio, T. Bird, B. Boeve, J. Bowen, A. Boxer, J. Burke, J. Burns, J. Buxbaum, N. Cairns, C. Cao, C. Carlson, C. Carlsson, R. Carney, M. Carrasquillo, S. Carroll, C. Diaz, H. Chui, D. G. Clark, D. Cribbs, E. Crocco, C. DeCarli, M. Dick, R. Duara, Denis A. Evans, K. Faber, K. Fallon, D. Fardo, M. Farlow, S. Ferris, T. Foroud, D. Galasko, M. Gearing, D. Geschwind, J. Gilbert, N. Graff-Radford, R. Green, J. Growdon, R. Hamilton, L. Harrell, L. Honig, M. Huentelman, C. Hulette, B. Hyman, G. Jarvik, E. Abner, Lee‐way Jin, G. Jun, A. Karydas, J. Kaye, R. Kim, N. Kowall, J. Kramer, F. LaFerla, J. Lah, J. Leverenz, A. Levey, Ge Li, A. Lieberman, K. Lunetta, C. Lyketsos, D. Marson, F. Martiniuk, D. Mash, E. Masliah, W. McCormick, S. McCurry, A. McDavid, A. Mckee, M. Mesulam, B. Miller, C. Miller, Joshua W. Miller, J. Morris, J. Murrell, A. Myers, S. O'Bryant, J. Olichney, V. Pankratz, J. Parisi, H. Paulson, W. Perry, E. Peskind, A. Pierce, W. Poon, H. Potter, J. Quinn, A. Raj, M. Raskind, B. Reisberg, C. Reitz, J. Ringman, E. Roberson, E. Rogaeva, H. Rosen, R. Rosenberg, M. Sager, A. Saykin, J. Schneider, L. Schneider, W. Seeley, Amanda G. Smith, J. Sonnen, S. Spina, R. Stern, R. Swerdlow, R. Tanzi, T. Thornton-Wells, J. Trojanowski, J. Troncoso, V. V. Van Deerlin, L. V. Van Eldik, H. Vinters, J. Vonsattel, S. Weintraub, K. Welsh-Bohmer, K. Wilhelmsen, J. Williamson, T. Wingo, R. Woltjer, C. Wright, Chang-En Yu, Lei Yu, F. Garzia, F. Golamaully, G. Septier, S. Engelborghs, R. Vandenberghe, P. D. de Deyn, C. M. Fernadez, Y. A. Benito, H. Thonberg, C. Forsell, L. Lilius, A. Kinhult-Stählbom, L. Kilander, R. Brundin, L. Concari, S. Helisalmi, A. Koivisto, A. Haapasalo, V. Dermecourt, N. Fievet, O. Hanon, C. Dufouil, A. Brice, K. Ritchie, B. Dubois, J. J. Himali, C. Keene, J. Tschanz, A. Fitzpatrick, W. Kukull, M. Norton, T. Aspelund, E. Larson, R. Munger, J. Rotter, R. Lipton, M. Bullido, A. Hofman, T. Montine, E. Coto, E. Boerwinkle, R. Petersen, V. Álvarez, F. Rivadeneira, E. Reiman, M. Gallo, C. O’Donnell, J. Reisch, A. Bruni, D. Royall, M. Dichgans, M. Sano, D. Galimberti, P. S. St George-Hyslop, E. Scarpini, D. Tsuang, M. Mancuso, U. Bonuccelli, A. Winslow, A. Daniele, Chuang‐Kuo Wu, O. Peters, B. Nacmias, M. Riemenschneider, R. Heun, C. Brayne, D. Rubinsztein, J. Bras, R. Guerreiro, A. Al-Chalabi, C. Shaw, J. Collinge, D. Mann, M. Tsolaki, J. Clarimón, R. Sussams, S. Lovestone, M. O’Donovan, M. Owen, T. Behrens, S. Mead, A. Goate, A. Uitterlinden, C. Holmes, Carlos Cruchaga, M. Ingelsson, D. Bennett, J. Powell, T. Golde, C. Graff, P. D. De Jager, K. Morgan, N. Ertekin-Taner, O. Combarros, B. Psaty, P. Passmore, S. Younkin, C. Berr, V. Gudnason, D. Rujescu, D. Dickson, J. Dartigues, A. Destefano, S. Ortega-Cubero, H. Hakonarson, D. Campion, M. Boada, J. Kauwe, L. Farrer, C. van Broeckhoven, M. Ikram, L. Jones, J. Haines, C. Tzourio, L. Launer, V. Escott-Price, R. Mayeux, J. Deleuze, N. Amin, P. Holmans, M. Pericak-Vance, P. Amouyel, C. V. van Duijn, A. Ramírez, Li-San Wang, J. Lambert, S. Seshadri, Julie Williams, G. Schellenberg +448 moresemanticscholar +1 more sourceMolecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed +12 morewiley +1 more sourceTranscriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal +16 morewiley +1 more source
